ATP12A Antibody (PACO25124)
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주문- SKU:
- PACO25124
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ATP12A Antibody (PACO25124) |
Antibody SKU: | PACO25124 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Potassium-transporting ATPase α chain 2 protein (171-306AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human skin tissue using PACO25124 at dilution of 1:100. | |
Immunofluorescent analysis of A431 cells using PACO25124 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues. |
Synonyms: | Potassium-transporting ATPase α chain 2 (EC 3.6.3.10) (Non-gastric H(+)/K(+) ATPase subunit alpha) (Proton pump), ATP12A, ATP1AL1 |
UniProt Protein Function: | ATP12A: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transporter; Energy Metabolism - oxidative phosphorylation; Transporter, ion channel; EC 3.6.3.10; Membrane protein, integral; Membrane protein, multi-pass; Hydrolase Chromosomal Location of Human Ortholog: 13q12.12|13q12.1-q12.3 Cellular Component: hydrogen:potassium-exchanging ATPase complex; intracellular membrane-bound organelle; plasma membrane Molecular Function:hydrogen:potassium-exchanging ATPase activity; sodium:potassium-exchanging ATPase activity Biological Process: ATP hydrolysis coupled proton transport; cellular potassium ion homeostasis; cellular sodium ion homeostasis; potassium ion import |
NCBI Summary: | The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
UniProt Code: | P54707 |
NCBI GenInfo Identifier: | 212287925 |
NCBI Gene ID: | 479 |
NCBI Accession: | P54707.3 |
UniProt Secondary Accession: | P54707,Q13816, Q13817, Q16734, Q5W035, Q8N5U2, |
UniProt Related Accession: | P54707 |
Molecular Weight: | 116,053 Da |
NCBI Full Name: | Potassium-transporting ATPase alpha chain 2 |
NCBI Synonym Full Names: | ATPase H+/K+ transporting non-gastric alpha2 subunit |
NCBI Official Symbol: | ATP12A |
NCBI Official Synonym Symbols: | HK; #945; ATP1AL1 |
NCBI Protein Information: | potassium-transporting ATPase alpha chain 2 |
UniProt Protein Name: | Potassium-transporting ATPase alpha chain 2 |
UniProt Synonym Protein Names: | Non-gastric H(+)/K(+) ATPase subunit alpha; Proton pump |
Protein Family: | Potassium-transporting ATPase |
UniProt Gene Name: | ATP12A |
UniProt Entry Name: | AT12A_HUMAN |