ATOH7 Antibody (PACO44607)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO44607
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ATOH7 Antibody (PACO44607) |
Antibody SKU: | PACO44607 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Protein atonal homolog 7 protein (47-152AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO44607 at dilution of 1:100. |
Background: | Transcription factor involved in the differentiation of retinal ganglion cells. |
Synonyms: | Protein atonal homolog 7 (Class A basic helix-loop-helix protein 13) (bHLHa13) (Helix-loop-helix protein hATH-5) (hATH5), ATOH7, ATH5 BHLHA13 |
UniProt Protein Function: | ATOH7: Transcription factor involved in the differentiation of retinal ganglion cells. Defects in ATOH7 are the cause of retinal non-attachment congenital non-syndromic (RNANC). A condition characterized by separation of the inner layers of the retina (neural retina) from the pigment epithelium. Clinical findings include lack of perception of light, massive retrolental mass, shallow anterior chamber, and nystagmus in otherwise normal individuals. RNANC is caused by a 6.5 kb deletion that spans a remote cis regulatory element 20 kb upstream from ATOH7. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 10q21.3|10q21.3-q22.1 Cellular Component: nucleus Molecular Function:protein dimerization activity; DNA binding Biological Process: circadian rhythm; transcription, DNA-dependent; regulation of transcription, DNA-dependent; optic nerve development; entrainment of circadian clock; cell differentiation Disease: Persistent Hyperplastic Primary Vitreous, Autosomal Recessive |
NCBI Summary: | This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q8N100 |
NCBI GenInfo Identifier: | 74750873 |
NCBI Gene ID: | 220202 |
NCBI Accession: | Q8N100.1 |
UniProt Related Accession: | Q8N100 |
Molecular Weight: | 152 |
NCBI Full Name: | Protein atonal homolog 7 |
NCBI Synonym Full Names: | atonal homolog 7 (Drosophila) |
NCBI Official Symbol: | ATOH7 |
NCBI Official Synonym Symbols: | Math5; NCRNA; RNANC; PHPVAR; bHLHa13 |
NCBI Protein Information: | protein atonal homolog 7; helix-loop-helix protein hATH-5; class A basic helix-loop-helix protein 13 |
UniProt Protein Name: | Protein atonal homolog 7 |
UniProt Synonym Protein Names: | Class A basic helix-loop-helix protein 13; bHLHa13; Helix-loop-helix protein hATH-5; hATH5 |
Protein Family: | Protein atonal |
UniProt Gene Name: | ATOH7 |
UniProt Entry Name: | ATOH7_HUMAN |
Antibodies |
Anti-ATOH7 Antibody (CAB7273) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |