UniProt Protein Function: | ATG4B: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.4.22.-; Autophagy; Protease; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: cytoplasm; cytosol Molecular Function:cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; protein binding Biological Process: autophagic vacuole formation; autophagy; C-terminal protein lipidation; macroautophagy; mitochondrion degradation; protein delipidation; protein processing; protein targeting to membrane; proteolysis |
NCBI Summary: | Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y4P1 |
NCBI GenInfo Identifier: | 296434400 |
NCBI Gene ID: | 23192 |
NCBI Accession: | Q9Y4P1.2 |
UniProt Secondary Accession: | Q9Y4P1,Q53NU4, Q6ZUV8, Q8WYM9, Q96K07, Q96K96, Q96SZ1 Q9Y2F2, B7WNK2, |
UniProt Related Accession: | Q9Y4P1 |
Molecular Weight: | 42,622 Da |
NCBI Full Name: | Cysteine protease ATG4B |
NCBI Synonym Full Names: | autophagy related 4B cysteine peptidase |
NCBI Official Symbol: | ATG4B |
NCBI Official Synonym Symbols: | APG4B; AUTL1 |
NCBI Protein Information: | cysteine protease ATG4B |
UniProt Protein Name: | Cysteine protease ATG4B |
UniProt Synonym Protein Names: | AUT-like 1 cysteine endopeptidase; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; hAPG4B |
Protein Family: | Cysteine protease |
UniProt Gene Name: | ATG4B |
UniProt Entry Name: | ATG4B_HUMAN |