ATG16L1 Antibody (PACO22184)
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주문- SKU:
- PACO22184
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ATG16L1 Antibody (PACO22184) |
Antibody SKU: | PACO22184 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from Internal of human ATG16L1. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from Jurkat cells, using ATG16L1 antibody. |
Background: | Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. |
Synonyms: | A16L1; APG16 autophagy 16-like; APG16-like 1; APG16L; APG16L beta |
UniProt Protein Function: | ATG16L1: Plays an essential role in autophagy. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Belongs to the WD repeat ATG16 family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, peripheral; Adaptor/scaffold; Autophagy Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: autophagic vacuole; axoneme; cytosol Molecular Function:identical protein binding; protein binding; small conjugating protein ligase activity Biological Process: autophagic vacuole formation; macroautophagy Disease: Inflammatory Bowel Disease 10 |
NCBI Summary: | The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010] |
UniProt Code: | Q676U5 |
NCBI GenInfo Identifier: | 62510482 |
NCBI Gene ID: | 55054 |
NCBI Accession: | Q676U5.2 |
UniProt Secondary Accession: | Q676U5,Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619 A3EXK9, A3EXL0, B6ZDH0, |
UniProt Related Accession: | Q676U5 |
Molecular Weight: | 49,486 Da |
NCBI Full Name: | Autophagy-related protein 16-1 |
NCBI Synonym Full Names: | autophagy related 16 like 1 |
NCBI Official Symbol: | ATG16L1 |
NCBI Official Synonym Symbols: | IBD10; WDR30; APG16L; ATG16A; ATG16L |
NCBI Protein Information: | autophagy-related protein 16-1 |
UniProt Protein Name: | Autophagy-related protein 16-1 |
UniProt Synonym Protein Names: | APG16-like 1 |
Protein Family: | Autophagy-related protein |
UniProt Gene Name: | ATG16L1 |
UniProt Entry Name: | A16L1_HUMAN |
Antibodies |
Anti-ATG16L1 Antibody (CAB11969) |
Anti-ATG16L1 Antibody (CAB14138) |
Anti-ATG16L1 Antibody (CAB1871) |
Anti-ATG16L1 Antibody (CAB3637) |
ATG16L1 Antibody (PACO04678) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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