ATG13 Antibody (PACO43014)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO43014
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ATG13 Antibody (PACO43014) |
Antibody SKU: | PACO43014 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Autophagy-related protein 13 protein (318-517AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human lung cancer using PACO43014 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43014 at dilution of 1:100. |
Background: | Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. |
Synonyms: | Autophagy-related protein 13, ATG13, KIAA0652 |
UniProt Protein Function: | ATG13: an autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. Phosphorylated by ULK1 and ULK2. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 and -2 via C-terminus. Three isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Vesicle; Autophagy Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: mitochondrion; cytosol Molecular Function:protein binding; protein kinase binding Biological Process: autophagic vacuole formation |
NCBI Summary: | The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016] |
UniProt Code: | O75143 |
NCBI GenInfo Identifier: | 20140441 |
NCBI Gene ID: | 9776 |
NCBI Accession: | O75143.1 |
UniProt Related Accession: | O75143 |
Molecular Weight: | Observed: 57 kDaPredicted: 57 kDa |
NCBI Full Name: | Autophagy-related protein 13 |
NCBI Synonym Full Names: | autophagy related 13 |
NCBI Official Symbol: | ATG13 |
NCBI Official Synonym Symbols: | KIAA0652; PARATARG8 |
NCBI Protein Information: | autophagy-related protein 13 |
UniProt Protein Name: | Autophagy-related protein 13 |
Protein Family: | Autophagy protein |
UniProt Gene Name: | ATG13 |
UniProt Entry Name: | ATG13_HUMAN |
Antibodies |
Anti-ATG13 Antibody (CAB0690) |
Anti-Phospho-ATG13-Ser355 Antibody (CABP1089) |
ATG13 Antibody (PACO07472) |
ATG13 Antibody (PACO07473) |
ATG13 Antibody (PACO10086) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |