ATF4 Antibody (PACO00637)
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주문- SKU:
- PACO00637
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ATF4 Antibody |
Antibody SKU: | PACO00637 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from human CREB-2 around the non-phosphorylation site of S245. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ATF4; CREB2; TXREB; Cyclic AMP-dependent transcription factor ATF-4; cAMP-dependent transcription factor ATF-4; Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding prot |
UniProt Protein Function: | ATF-4: a transcription factor that is a member of the leucine zipper family. Isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). Involved in cisplatin resistance. Other members of the family include AP-1 transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: nucleoplasm; neuron projection; cytoplasm; microtubule organizing center; nucleus Molecular Function:protein C-terminus binding; leucine zipper domain binding; protein binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity Biological Process: amino acid metabolic process; transcription from RNA polymerase II promoter; positive regulation of apoptosis; unfolded protein response; positive regulation of transcription, DNA-dependent; negative regulation of potassium ion transport; positive regulation of transcription from RNA polymerase I promoter; gluconeogenesis; cellular response to glucose starvation; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; regulation of transcription, DNA-dependent; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; gamma-aminobutyric acid signaling pathway |
NCBI Summary: | This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011] |
UniProt Code: | P18848 |
NCBI GenInfo Identifier: | 116241262 |
NCBI Gene ID: | 468 |
NCBI Accession: | P18848.3 |
UniProt Secondary Accession: | P18848,Q9UH31, |
UniProt Related Accession: | P18848 |
Molecular Weight: | Calculated Molecular Weight: 38kDaObserved Molecular Weight: 38kDa |
NCBI Full Name: | Cyclic AMP-dependent transcription factor ATF-4 |
NCBI Synonym Full Names: | activating transcription factor 4 |
NCBI Official Symbol: | ATF4 |
NCBI Official Synonym Symbols: | CREB2; TXREB; CREB-2; TAXREB67 |
NCBI Protein Information: | cyclic AMP-dependent transcription factor ATF-4; DNA-binding protein TAXREB67; tax-responsive enhancer element B67; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; cyclic AMP-responsive element-binding protein 2; tax-responsive enhancer element-binding protein 67 |
UniProt Protein Name: | Cyclic AMP-dependent transcription factor ATF-4 |
UniProt Synonym Protein Names: | Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; Tax-responsive enhancer element-binding protein 67; TaxREB67 |
Protein Family: | Cyclic AMP-dependent transcription factor |
UniProt Gene Name: | ATF4 |
UniProt Entry Name: | ATF4_HUMAN |