ASNA1 Antibody (PACO43781)
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주문- SKU:
- PACO43781
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ASNA1 Antibody (PACO43781) |
Antibody SKU: | PACO43781 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human ATPase ASNA1 protein (1-348AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO43781 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO43781 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling. |
Synonyms: | ATPase ASNA1 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Transmembrane domain recognition complex 40 kDa ATPase subunit) (hARSA-I) (hASNA-I), ASNA1, ARSA TRC40 |
UniProt Protein Function: | ASNA1: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. Belongs to the arsA ATPase family. |
UniProt Protein Details: | Protein type:Nucleolus; EC 3.6.-.-; EC 3.6.3.16; Hydrolase Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: endoplasmic reticulum; cytoplasm; nucleolus; nucleus Molecular Function:arsenite transmembrane transporter activity; transporter activity; metal ion binding; ATPase activity; ATP binding Biological Process: protein insertion into ER membrane; transport; metabolic process; inorganic anion transport |
NCBI Summary: | This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011] |
UniProt Code: | O43681 |
NCBI GenInfo Identifier: | 6647417 |
NCBI Gene ID: | 439 |
NCBI Accession: | O43681.2 |
UniProt Secondary Accession: | O43681,Q53FC6, Q92849, A6NHP8, A8K740, |
UniProt Related Accession: | O43681 |
Molecular Weight: | Calculated: 38kDaObserved: 39kDa |
NCBI Full Name: | ATPase ASNA1 |
NCBI Synonym Full Names: | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) |
NCBI Official Symbol: | ASNA1 |
NCBI Official Synonym Symbols: | GET3; ARSA1; TRC40; ARSA-I; ASNA-I; hASNA-I |
NCBI Protein Information: | ATPase ASNA1; golgi to ER traffic 3 homolog; transmembrane domain recognition complex, 40kDa; transmembrane domain recognition complex 40 kDa ATPase subunit |
UniProt Protein Name: | ATPase ASNA1 |
UniProt Synonym Protein Names: | Arsenical pump-driving ATPase; Arsenite-stimulated ATPase |
Protein Family: | ATPase |
UniProt Gene Name: | ASNA1 |
UniProt Entry Name: | ASNA_HUMAN |