ASF1A Antibody (PACO44132)
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주문- SKU:
- PACO44132
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ASF1A Antibody (PACO44132) |
Antibody SKU: | PACO44132 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Histone chaperone ASF1A protein (1-204AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: ASF1A antibody at 2µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: A431 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 23 kDa. Observed band size: 23 kDa.. | |
Immunohistochemistry of paraffin-embedded human colon tissue using PACO44132 at dilution of 1:100. |
Background: | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. |
Synonyms: | Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA), ASF1A |
UniProt Protein Function: | ASF1A: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Ubiquitously expressed. Belongs to the ASF1 family. |
UniProt Protein Details: | Protein type:DNA repair, damage; Histone-binding Chromosomal Location of Human Ortholog: 6q22.31 Cellular Component: nuclear chromatin; nucleoplasm; nucleus; protein complex Molecular Function:chromatin binding; histone binding; protein binding Biological Process: chromatin modification; DNA repair; DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; muscle cell differentiation; negative regulation of chromatin silencing; nucleosome assembly; osteoblast differentiation; transcription, DNA-dependent |
NCBI Summary: | This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y294 |
NCBI GenInfo Identifier: | 74735206 |
NCBI Gene ID: | 25842 |
NCBI Accession: | Q9Y294.1 |
UniProt Secondary Accession: | Q9Y294,Q6IA08, Q9P014, |
UniProt Related Accession: | Q9Y294 |
Molecular Weight: | 22,969 Da |
NCBI Full Name: | Histone chaperone ASF1A |
NCBI Synonym Full Names: | anti-silencing function 1A histone chaperone |
NCBI Official Symbol: | ASF1A |
NCBI Official Synonym Symbols: | CIA; CGI-98; HSPC146 |
NCBI Protein Information: | histone chaperone ASF1A |
UniProt Protein Name: | Histone chaperone ASF1A |
UniProt Synonym Protein Names: | Anti-silencing function protein 1 homolog A; hAsf1; hAsf1a; CCG1-interacting factor A; CIA; hCIA |
Protein Family: | Histone chaperone |
UniProt Gene Name: | ASF1A |
UniProt Entry Name: | ASF1A_HUMAN |
Antibodies |
Anti-ASF1A Antibody (CAB14508) |
Anti-ASF1A Antibody (CAB6528) |
Anti-ASF1A Antibody (CAB17124) |
ASF1A Antibody (PACO00434) |
ASF1A Antibody (PACO07880) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |