ASCC3 Antibody (PACO43579)
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주문- SKU:
- PACO43579
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ASCC3 Antibody (PACO43579) |
Antibody SKU: | PACO43579 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Activating signal cointegrator 1 complex subunit 3 protein (1-111AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43579 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO43579 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO43579 at dilution of 1:100. |
Background: | 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation.1 Publication |
Synonyms: | Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200), ASCC3, HELIC1 |
UniProt Protein Function: | ASCC3: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation. Belongs to the helicase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.6.4.12; Helicase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 6q16 Cellular Component: Golgi apparatus; membrane; cytoplasm; intracellular; nucleus Molecular Function:protein binding; ATP-dependent 3'-5' DNA helicase activity; ATP binding Biological Process: cell proliferation; DNA dealkylation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; DNA duplex unwinding |
NCBI Summary: | This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
UniProt Code: | Q8N3C0 |
NCBI GenInfo Identifier: | 158518649 |
NCBI Gene ID: | 10973 |
NCBI Accession: | Q8N3C0.3 |
UniProt Related Accession: | Q8N3C0 |
Molecular Weight: | 160kDa |
NCBI Full Name: | Activating signal cointegrator 1 complex subunit 3 |
NCBI Synonym Full Names: | activating signal cointegrator 1 complex subunit 3 |
NCBI Official Symbol: | ASCC3 |
NCBI Official Synonym Symbols: | RNAH; HELIC1; ASC1p200 |
NCBI Protein Information: | activating signal cointegrator 1 complex subunit 3 |
UniProt Protein Name: | Activating signal cointegrator 1 complex subunit 3 |
UniProt Synonym Protein Names: | ASC-1 complex subunit p200; ASC1p200; Helicase, ATP binding 1; Trip4 complex subunit p200 |
Protein Family: | Activating signal cointegrator 1 complex |
UniProt Gene Name: | ASCC3 |
UniProt Entry Name: | ASCC3_HUMAN |