ASCC2 Antibody (PACO19254)
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주문- SKU:
- PACO19254
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ASCC2 Antibody (PACO19254) |
Antibody SKU: | PACO19254 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human ASCC2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A431 cells, 293T cells, hela cells, Primary antibody: PACO19254(ASCC2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. |
Background: | ASCC2 (activating signal cointegrator 1 complex subunit 2), also known as ASC1P100, is a 757 amino acid, protein that is ubiquitously expressed and contains one CUE domain. The gene encoding ASCC2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias. |
Synonyms: | activating signal cointegrator 1 complex subunit 2 |
UniProt Protein Function: | ASCC2: Enhances NF-kappa-B, SRF and AP1 transactivation. Belongs to the ASCC2 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 22q12.1 Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent |
UniProt Code: | Q9H1I8 |
NCBI GenInfo Identifier: | 92090990 |
NCBI Gene ID: | 84164 |
NCBI Accession: | Q9H1I8.3 |
UniProt Secondary Accession: | Q9H1I8,Q4TT54, Q8TAZ0, Q9H711, Q9H9D6, B7Z8E0, F5H6J9 |
UniProt Related Accession: | Q9H1I8 |
Molecular Weight: | 77,369 Da |
NCBI Full Name: | Activating signal cointegrator 1 complex subunit 2 |
NCBI Synonym Full Names: | activating signal cointegrator 1 complex subunit 2 |
NCBI Official Symbol: | ASCC2 |
NCBI Official Synonym Symbols: | p100; ASC1p100 |
NCBI Protein Information: | activating signal cointegrator 1 complex subunit 2; ASC-1 complex subunit P100; trip4 complex subunit p100 |
UniProt Protein Name: | Activating signal cointegrator 1 complex subunit 2 |
UniProt Synonym Protein Names: | ASC-1 complex subunit p100; Trip4 complex subunit p100 |
Protein Family: | Activating signal cointegrator 1 complex |
UniProt Gene Name: | ASCC2 |
UniProt Entry Name: | ASCC2_HUMAN |