ASB7 Antibody (PACO40574)
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주문- SKU:
- PACO40574
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ASB7 Antibody (PACO40574) |
Antibody SKU: | PACO40574 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Ankyrin repeat and SOCS box protein 7 protein (1-274AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: ASB7 antibody at 8µg/ml + A431 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 37, 31 kDa. Observed band size: 37 kDa. | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO40574 at dilution of 1:100. |
Background: | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
Synonyms: | Ankyrin repeat and SOCS box protein 7 (ASB-7), ASB7 |
UniProt Protein Function: | ASB7: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 15q26.3 Molecular Function:protein binding |
NCBI Summary: | The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9H672 |
NCBI GenInfo Identifier: | 38372887 |
NCBI Gene ID: | 140460 |
NCBI Accession: | Q9H672.2 |
UniProt Secondary Accession: | Q9H672,Q6GSJ6, Q7Z4S3, A8K1E5, |
UniProt Related Accession: | Q9H672 |
Molecular Weight: | 30,713 Da |
NCBI Full Name: | Ankyrin repeat and SOCS box protein 7 |
NCBI Synonym Full Names: | ankyrin repeat and SOCS box containing 7 |
NCBI Official Symbol: | ASB7 |
NCBI Protein Information: | ankyrin repeat and SOCS box protein 7 |
UniProt Protein Name: | Ankyrin repeat and SOCS box protein 7 |
Protein Family: | Ankyrin repeat and SOCS box protein |
UniProt Gene Name: | ASB7 |
UniProt Entry Name: | ASB7_HUMAN |
Antibodies |
Anti-ASB7 Antibody (CAB16596) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |