ASB4 Antibody (PACO15784)
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주문- SKU:
- PACO15784
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ASB4 Antibody (PACO15784) |
Antibody SKU: | PACO15784 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human ASB4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15784(ASB4 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. |
Synonyms: | ankyrin repeat and SOCS box containing 4 |
UniProt Protein Function: | ASB4: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 7q21-q22 Cellular Component: Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex |
NCBI Summary: | The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y574 |
NCBI GenInfo Identifier: | 20532003 |
NCBI Gene ID: | 51666 |
NCBI Accession: | Q9Y574.1 |
UniProt Secondary Accession: | Q9Y574,O14586, Q14D68, Q8TBT2, A4D1H6, |
UniProt Related Accession: | Q9Y574 |
Molecular Weight: | 38,931 Da |
NCBI Full Name: | Ankyrin repeat and SOCS box protein 4 |
NCBI Synonym Full Names: | ankyrin repeat and SOCS box containing 4 |
NCBI Official Symbol: | ASB4 |
NCBI Official Synonym Symbols: | ASB-4 |
NCBI Protein Information: | ankyrin repeat and SOCS box protein 4 |
UniProt Protein Name: | Ankyrin repeat and SOCS box protein 4 |
Protein Family: | Ankyrin repeat and SOCS box protein |
UniProt Gene Name: | ASB4 |
UniProt Entry Name: | ASB4_HUMAN |
Antibodies |
Anti-ASB4 Antibody (CAB17159) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |