ARHGDIA Antibody (PACO24664)
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주문- SKU:
- PACO24664
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ARHGDIA Antibody (PACO24664) |
Antibody SKU: | PACO24664 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Rho GDP-dissociation inhibitor 1 protein (2-204AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: ARHGDIA antibody at 2µg/ml Lane 1: EC109 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 24, 19 kDa Observed band size: 40 kDa . | |
Immunohistochemistry of paraffin-embedded human mammary gland tissue using PACO24664 at dilution of 1:50. |
Background: | Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them |
Synonyms: | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha), ARHGDIA, GDIA1 |
UniProt Protein Function: | RhoGDI alpha: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Monomer. Forms a heterodimer with RAC1. Interacts with FER. Belongs to the Rho GDI family. |
UniProt Protein Details: | Protein type:Apoptosis; Cell development/differentiation; G protein regulator, misc.; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: cytoskeleton; cytosol Molecular Function:GTPase activator activity; protein binding; Rho GDP-dissociation inhibitor activity Biological Process: cell motility; negative regulation of apoptosis; negative regulation of axonogenesis; negative regulation of cell adhesion; nerve growth factor receptor signaling pathway; positive regulation of axonogenesis; positive regulation of GTPase activity; regulation of axonogenesis; regulation of catalytic activity; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; small GTPase mediated signal transduction Disease: Nephrotic Syndrome, Type 8 |
NCBI Summary: | This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
UniProt Code: | P52565 |
NCBI GenInfo Identifier: | 1707892 |
NCBI Gene ID: | 396 |
NCBI Accession: | P52565.3 |
UniProt Secondary Accession: | P52565,Q6IBM5, A8MXW0, B2R5X1, B4DDD3, B4DUV9, |
UniProt Related Accession: | P52565 |
Molecular Weight: | 18,233 Da |
NCBI Full Name: | Rho GDP-dissociation inhibitor 1 |
NCBI Synonym Full Names: | Rho GDP dissociation inhibitor alpha |
NCBI Official Symbol: | ARHGDIA |
NCBI Official Synonym Symbols: | GDIA1; NPHS8; RHOGDI; RHOGDI-1; HEL-S-47e |
NCBI Protein Information: | rho GDP-dissociation inhibitor 1 |
UniProt Protein Name: | Rho GDP-dissociation inhibitor 1 |
UniProt Synonym Protein Names: | Rho-GDI alpha |
UniProt Gene Name: | ARHGDIA |
UniProt Entry Name: | GDIR1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |