AQP4 Antibody (PACO32960)
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주문- SKU:
- PACO32960
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | AQP4 Antibody (PACO32960) |
Antibody SKU: | PACO32960 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:200-1:500, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Aquaporin-4 protein (253-323AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: AQP4 antibody at 2µg/ml Lane 1: Mouse heart tissue Lane 2: Mouse brain tissue Lane 3: Mouse kidney tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 35, 33 kDa Observed band size: 35 kDa . | |
IHC image of PACO32960 diluted at 1:370 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
IHC image of PACO32960 diluted at 1:370 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. |
Synonyms: | Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4), AQP4 |
UniProt Protein Function: | AQP4: a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The predominant aquaporin found in brain. Two alternatively spliced transcript variants have been described |
UniProt Protein Details: | Protein type:Transporter, aquaporin family; Membrane protein, integral; Channel, misc.; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 18q11.2-q12.1 Cellular Component: basolateral plasma membrane; cytoplasm; external side of plasma membrane; integral to membrane; plasma membrane Molecular Function:glycerol channel activity; water channel activity; water transporter activity Biological Process: glycerol transport; multicellular organismal water homeostasis; renal water homeostasis; transmembrane transport; transport; water transport |
NCBI Summary: | This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015] |
UniProt Code: | P55087 |
NCBI GenInfo Identifier: | 2506859 |
NCBI Gene ID: | 361 |
NCBI Accession: | P55087.2 |
UniProt Secondary Accession: | P55087,P78564, |
UniProt Related Accession: | P55087 |
Molecular Weight: | 32,300 Da |
NCBI Full Name: | Aquaporin-4 |
NCBI Synonym Full Names: | aquaporin 4 |
NCBI Official Symbol: | AQP4 |
NCBI Official Synonym Symbols: | MIWC; WCH4 |
NCBI Protein Information: | aquaporin-4 |
UniProt Protein Name: | Aquaporin-4 |
UniProt Synonym Protein Names: | Mercurial-insensitive water channel; MIWC; WCH4 |
Protein Family: | Aquaporin |
UniProt Gene Name: | AQP4 |
UniProt Entry Name: | AQP4_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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