APOBEC3G Antibody (PACO15482)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO15482
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | APOBEC3G Antibody (PACO15482) |
Antibody SKU: | PACO15482 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human APOBEC3G |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO15482(APOBEC3G Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: PC3 cells, Jurkat cells, Raji cells, Primary antibody: PACO15482(APOBEC3G Antibody) at dilution 1/240, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15482(APOBEC3G Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. |
Synonyms: | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G |
UniProt Protein Function: | APOBEC3G: DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. May also prevent the transposition of a subset of retroelements. Binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing. Belongs to the cytidine and deoxycytidylate deaminase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA-binding; EC 3.5.4.-; Hydrolase; RNA processing Chromosomal Location of Human Ortholog: 22q13.1-q13.2 Cellular Component: apolipoprotein B mRNA editing enzyme complex; cytoplasm; cytosol; ribonucleoprotein complex Molecular Function:protein binding; protein homodimerization activity; deoxycytidine deaminase activity; zinc ion binding; RNA binding; cytidine deaminase activity Biological Process: negative regulation of retroviral genome replication; base conversion or substitution editing; viral reproduction; negative regulation of viral genome replication; innate immune response; cytidine deamination; positive regulation of defense response to virus by host; negative regulation of viral reproduction; defense response to virus |
NCBI Summary: | This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene catalyzes site-specific deamination of both RNA and single-stranded DNA. The encoded protein has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Mar 2017] |
UniProt Code: | Q9HC16 |
NCBI GenInfo Identifier: | 44887683 |
NCBI Gene ID: | 60489 |
NCBI Accession: | Q9HC16.1 |
UniProt Related Accession: | Q9HC16 |
Molecular Weight: | |
NCBI Full Name: | DNA dC-> |
NCBI Synonym Full Names: | apolipoprotein B mRNA editing enzyme catalytic subunit 3G |
NCBI Official Symbol: | APOBEC3G |
NCBI Official Synonym Symbols: | A3G; ARCD; ARP9; ARP-9; CEM15; CEM-15; MDS019; bK150C2.7; dJ494G10.1 |
NCBI Protein Information: | DNA dC->dU-editing enzyme APOBEC-3G |
UniProt Protein Name: | DNA dC->dU-editing enzyme APOBEC-3G |
UniProt Synonym Protein Names: | APOBEC-related cytidine deaminase; APOBEC-related protein; ARCD; APOBEC-related protein 9; ARP-9; CEM-15; CEM15; Deoxycytidine deaminase; A3G |
UniProt Gene Name: | APOBEC3G |
UniProt Entry Name: | ABC3G_HUMAN |
Antibodies |
Anti-APOBEC3G Antibody (CAB13598) |
Anti-APOBEC3G Antibody (CAB1459) |
Anti-APOBEC3G Antibody (CAB17199) |
APOBEC3G Antibody (PACO07791) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |