APOBEC3C Antibody (PACO44072)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO44072
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | APOBEC3C Antibody (PACO44072) |
Antibody SKU: | PACO44072 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human DNA dC->dU-editing enzyme APOBEC-3C protein (1-190AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: APOBEC3C antibody at 3µg/ml + K562 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 23 kDa. Observed band size: 23 kDa.. | |
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO44072 at dilution of 1:100. |
Background: | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. |
Synonyms: | DNA dC->dU-editing enzyme APOBEC-3C (A3C) (EC 3.5.4.-) (APOBEC1-like) (Phorbolin I), APOBEC3C, APOBEC1L PBI |
UniProt Protein Function: | APOBEC3C: Host cellular restriction factor that may have antiviral activities against exogenous and endogenous viruses, as well as retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Belongs to the cytidine and deoxycytidylate deaminase family. |
UniProt Protein Details: | Protein type:Hydrolase; EC 3.5.4.-; RNA-binding Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: cytoplasm; nucleus Molecular Function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; protein binding; zinc ion binding Biological Process: cytidine deamination; defense response to virus; innate immune response; negative regulation of viral genome replication; viral reproduction |
NCBI Summary: | This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NRW3 |
NCBI GenInfo Identifier: | 48474983 |
NCBI Gene ID: | 27350 |
NCBI Accession: | Q9NRW3.2 |
UniProt Secondary Accession: | Q9NRW3,Q5JZ92, Q7Z2N7, Q96F12, B2R884, |
UniProt Related Accession: | Q9NRW3 |
Molecular Weight: | 22,826 Da |
NCBI Full Name: | DNA dC-> |
NCBI Synonym Full Names: | apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C |
NCBI Official Symbol: | APOBEC3C |
NCBI Official Synonym Symbols: | A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3 |
NCBI Protein Information: | DNA dC->dU-editing enzyme APOBEC-3C |
UniProt Protein Name: | DNA dC->dU-editing enzyme APOBEC-3C |
UniProt Synonym Protein Names: | APOBEC1-like; Phorbolin I |
Protein Family: | DNA dC->dU-editing enzyme |
UniProt Gene Name: | APOBEC3C |
UniProt Entry Name: | ABC3C_HUMAN |
Antibodies |
Anti-APOBEC3C Antibody (CAB14510) |
Anti-APOBEC3C Antibody (CAB5877) |
APOBEC3C Antibody (PACO07790) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |