API5 Antibody (PACO19128)
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주문- SKU:
- PACO19128
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | API5 Antibody (PACO19128) |
Antibody SKU: | PACO19128 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human API5 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, MCF7 cells, A549 cells, Lovo cells, Primary antibody: PACO19128(API5 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
Background: | This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
Synonyms: | apoptosis inhibitor 5 |
UniProt Protein Function: | API5: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Belongs to the API5 family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA-binding; Apoptosis Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: nucleoplasm; spliceosome; membrane; cytoplasm; nucleus Molecular Function:protein binding; fibroblast growth factor binding Biological Process: apoptosis; negative regulation of apoptosis |
NCBI Summary: | This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q9BZZ5 |
NCBI GenInfo Identifier: | 353526346 |
NCBI Gene ID: | 8539 |
NCBI Accession: | Q9BZZ5.3 |
UniProt Secondary Accession: | Q9BZZ5,O15441, Q9Y4J7, B4DGR0, B4DRJ2, D3DR21, |
UniProt Related Accession: | Q9BZZ5 |
Molecular Weight: | 50,740 Da |
NCBI Full Name: | Apoptosis inhibitor 5 |
NCBI Synonym Full Names: | apoptosis inhibitor 5 |
NCBI Official Symbol: | API5 |
NCBI Official Synonym Symbols: | AAC11; AAC-11 |
NCBI Protein Information: | apoptosis inhibitor 5; FIF; antiapoptosis clone 11 protein; migration-inducing protein MIG8; cell migration-inducing gene 8 protein; fibroblast growth factor 2-interacting factor 2 |
UniProt Protein Name: | Apoptosis inhibitor 5 |
UniProt Synonym Protein Names: | Antiapoptosis clone 11 protein; AAC-11; Cell migration-inducing gene 8 protein; Fibroblast growth factor 2-interacting factor; FIF; Protein XAGL |
Protein Family: | Apoptosis inhibitor |
UniProt Gene Name: | API5 |
UniProt Entry Name: | API5_HUMAN |
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