UniProt Protein Function: | ABP1: Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function. Belongs to the copper/topaquinone oxidase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - arginine and proline; Secreted; Amino Acid Metabolism - tryptophan; Oxidoreductase; Secreted, signal peptide; EC 1.4.3.22; Amino Acid Metabolism - histidine Chromosomal Location of Human Ortholog: 7q36.1 Cellular Component: extracellular space; tight junction; plasma membrane; peroxisome Molecular Function:amine oxidase activity; heparin binding; copper ion binding; protein homodimerization activity; zinc ion binding; protein complex binding; calcium ion binding; receptor activity; cation channel activity; drug binding; sodium channel activity; quinone binding Biological Process: response to antibiotic; response to drug; amine metabolic process |
NCBI Summary: | This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013] |
UniProt Code: | P19801 |
NCBI GenInfo Identifier: | 251757489 |
NCBI Gene ID: | 26 |
NCBI Accession: | P19801.4 |
UniProt Secondary Accession: | P19801,Q16683, Q16684, Q56II4, Q6GU42, C9J690, |
UniProt Related Accession: | P19801 |
Molecular Weight: | 87,239 Da |
NCBI Full Name: | Amiloride-sensitive amine oxidase |
NCBI Synonym Full Names: | amine oxidase, copper containing 1 |
NCBI Official Symbol: | AOC1 |
NCBI Official Synonym Symbols: | ABP; DAO; KAO; ABP1; DAO1 |
NCBI Protein Information: | amiloride-sensitive amine oxidase [copper-containing]; amiloride-sensitive amine oxidase [copper-containing]; amiloride binding protein 1 (amine oxidase (copper-containing)); amiloride-binding protein 1; amine oxidase copper domain-containing protein 1; diamine oxidase; histaminase; kidney amine oxidase |
UniProt Protein Name: | Amiloride-sensitive amine oxidase [copper-containing] |
UniProt Synonym Protein Names: | Amiloride-binding protein 1; Amine oxidase copper domain-containing protein 1; Histaminase; Kidney amine oxidase; KAO |
Protein Family: | D-amino-acid oxidase |
UniProt Gene Name: | AOC1 |
UniProt Entry Name: | AOC1_HUMAN |