Anti-UBA7 Antibody (CAB9142)
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주문- SKU:
- CAB9142
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- UBA7
- Synonyms:
- D8
- Synonyms:
- UBA1B
- Synonyms:
- UBE1L
- Synonyms:
- UBE2
Frequently bought together:
Description
| Product Name: | UBA7 Rabbit pAb |
| Product Code: | CAB9142 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | UBA7, D8, UBA1B, UBE1L, UBE2 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 723-1012 of human UBA7 (NP_003326.2). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:200 - 1:2000 |
| Reactivity: | Human |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 723-1012 of human UBA7 (NP_003326.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | THLL YVLA AANL YAQM HGLP GSQD WTAL RELL KLLP QPDP QQMA PIFA SNLE LASA SAEF GPEQ QKEL NKAL EVWS VGPP LKPL MFEK DDDS NFHV DFVV AAAS LRCQ NYGI PPVN RAQS KRIV GQII PAIA TTTA AVAG LLGL ELYK VVSG PRPR SAFR HSYL HLAE NYLI RYMP FAPA IQTF HHLK WTSW DRLK VPAG QPER TLES LLAH LQEQ HGLR VRIL LHGS ALLY AAGW SPEK QAQH LPLR VTEL VQQL TGQA PAPG QRVL VLEL SCEG DDED TAFP PLHY EL |
| Gene ID: | 7318 |
| Uniprot: | P41226 |
| Calculated MW: | 111kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | UBE1L: Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Belongs to the ubiquitin-activating E1 family. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19 Chromosomal Location of Human Ortholog: 3p21 Cellular Component: cytosol; nucleoplasm; nucleus Molecular Function:ISG15 activating enzyme activity; protein binding; ubiquitin activating enzyme activity; ubiquitin-protein ligase activity Biological Process: bypass DNA synthesis; ISG15-protein conjugation; modification-dependent protein catabolic process; negative regulation of interferon type I production; protein modification process |
| NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P41226 |
| NCBI GenInfo Identifier: | 215273977 |
| NCBI Gene ID: | 7318 |
| NCBI Accession: | P41226.2 |
| UniProt Secondary Accession: | P41226,Q9BRB2, |
| UniProt Related Accession: | P41226 |
| Molecular Weight: | 111,694 Da |
| NCBI Full Name: | Ubiquitin-like modifier-activating enzyme 7 |
| NCBI Synonym Full Names: | ubiquitin like modifier activating enzyme 7 |
| NCBI Official Symbol: | UBA7 |
| NCBI Official Synonym Symbols: | D8; UBE2; UBA1B; UBE1L |
| NCBI Protein Information: | ubiquitin-like modifier-activating enzyme 7 |
| UniProt Protein Name: | Ubiquitin-like modifier-activating enzyme 7 |
| UniProt Synonym Protein Names: | D8; Ubiquitin-activating enzyme E1 homolog |
| Protein Family: | Ubiquitin-like modifier-activating enzyme |
| UniProt Gene Name: | UBA7 |
| UniProt Entry Name: | UBA7_HUMAN |
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