Anti-TMEM173 Antibody (RACO0421)
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주문- SKU:
- RACO0421
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Conjugation:
- Unconjugated
Description
Product Name: | TMEM173 Antibody |
Product SKU: | RACO0421 |
Size: | 50ul |
Host Species: | Homo sapiens (Human) |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:5000 |
Species Reactivity: | Human |
Immunogen: | A synthesized peptide derived from human TMEM173 |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263). |
Synonyms: | Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173), TMEM173, ERIS MITA STING |
Western Blot. Positive WB detected in 293 whole cell lysate HepG2 whole cell lysate Jurkat whole cell lysate THP-1 whole cell lysate All lanes TMEM173 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 43 kDa. Observed band size: 43 kDa. |
UniProt Protein Function: | TMEM173: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Associates with the MHC-II complex. Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS/VISA and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Ubiquitously expressed. Belongs to the TMEM173 family. |
UniProt Protein Details: | Protein type:Mitochondrial; Membrane protein, multi-pass; Apoptosis; Membrane protein, integral; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 5q31.2 Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; mitochondrial outer membrane; cytoplasmic vesicle membrane; perinuclear region of cytoplasm; plasma membrane; integral to membrane; peroxisome Molecular Function:identical protein binding; protein binding; protein homodimerization activity; ubiquitin protein ligase binding; transcription factor binding; protein kinase binding Biological Process: regulation of interferon type I production; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; apoptosis; positive regulation of interferon type I production; positive regulation of transcription factor import into nucleus; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of defense response to virus by host; activation of innate immune response; defense response to virus; interferon-beta production Disease: Sting-associated Vasculopathy, Infantile-onset |
NCBI Summary: | This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014] |
UniProt Code: | Q86WV6 |
NCBI GenInfo Identifier: | 74727720 |
NCBI Gene ID: | 340061 |
NCBI Accession: | Q86WV6.1 |
UniProt Secondary Accession: | Q86WV6,A8K3P6, B6EB35, D6RBX0, D6RE01, D6RID9, |
UniProt Related Accession: | Q86WV6 |
Molecular Weight: | Observed MW: 39kDa; Calculated MW 42kDa |
NCBI Full Name: | Stimulator of interferon genes protein |
NCBI Synonym Full Names: | transmembrane protein 173 |
NCBI Official Symbol: | TMEM173Â Â |
NCBI Official Synonym Symbols: | ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTINGÂ Â |
NCBI Protein Information: | stimulator of interferon genes protein; endoplasmic reticulum IFN stimulator; mitochondrial mediator of IRF3 activation; endoplasmic reticulum interferon stimulator; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner |
UniProt Protein Name: | Stimulator of interferon genes protein |
UniProt Synonym Protein Names: | Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Transmembrane protein 173 |
Protein Family: | Stimulator of interferon genes protein |
UniProt Gene Name: | TMEM173Â Â |
UniProt Entry Name: | STING_HUMAN |