Anti-TACC3 Antibody (RACO0529)
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주문- SKU:
- RACO0529
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Product Name: | TACC3 Antibody |
Product SKU: | RACO0529 |
Size: | 50ul |
Host Species: | Homo sapiens (Human) |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | A synthesized peptide derived from human TACC3 |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). |
Synonyms: | Transforming acidic coiled-coil-containing protein 3 (ERIC-1), TACC3, ERIC1 |
IHC image of RACO0529 diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. | |
Western Blot. Positive WB detected in K562 whole cell lysate THP-1 whole cell lysate All lanes TACC3 Antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 91 kDa. Observed band size: 140 kDa. |
UniProt Protein Function: | TACC3: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May be involved in the control of cell growth and differentiation. May contribute to cancer. Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2. Interacts with GCN5L2 and PCAF. Up-regulated in various cancer cell lines. Belongs to the TACC family. |
UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: centrosome; cytoplasm Molecular Function:protein domain specific binding; protein binding Biological Process: regulation of microtubule-based process; cell proliferation; cytoplasmic sequestering of transcription factor; astral microtubule organization and biogenesis; neurogenesis; regulation of cell cycle; response to hypoxia; hemopoiesis; microtubule cytoskeleton organization and biogenesis; cerebral cortex development; interkinetic nuclear migration Disease: Bladder Cancer |
NCBI Summary: | The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice. [provided by RefSeq] |
UniProt Code: | Q9Y6A5 |
NCBI GenInfo Identifier: | 5454102 |
NCBI Gene ID: | 10460 |
NCBI Accession: | NP_006333.1 |
UniProt Related Accession: | Q2NKK4,Q8IX09,Q9Y6A5 |
Molecular Weight: | 90,522 Da |
NCBI Full Name: | transforming acidic coiled-coil-containing protein 3 |
NCBI Synonym Full Names: | transforming, acidic coiled-coil containing protein 3 |
NCBI Official Symbol: | TACC3Â Â |
NCBI Official Synonym Symbols: | ERIC1; ERIC-1; MGC117382; MGC133242Â Â |
NCBI Protein Information: | transforming acidic coiled-coil-containing protein 3; OTTHUMP00000113796 |
UniProt Protein Name: | Transforming, acidic coiled-coil containing protein 3 |
Protein Family: | Transforming acidic coiled-coil-containing protein |
UniProt Gene Name: | TACC3Â Â |
UniProt Entry Name: | Q2NKK4_HUMAN |