Anti-SNAP23 Antibody (RACO0542)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- RACO0542
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Product Name: | SNAP23 Antibody |
Product SKU: | RACO0542 |
Size: | 50ul |
Host Species: | Homo sapiens (Human) |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | A synthesized peptide derived from human SNAP23 |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. |
Synonyms: | Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23), SNAP23 |
IHC image of RACO0542 diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
UniProt Protein Function: | SNAP23: a member of the SNAP-25 family of SNARE proteins. Structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 15q14 Cellular Component: nucleoplasm; SNARE complex; azurophil granule; specific granule; neuron projection; mast cell granule; focal adhesion; cytoplasm; plasma membrane; synapse Molecular Function:SNAP receptor activity; protein binding; syntaxin binding Biological Process: synaptic vesicle fusion to presynaptic membrane; protein transport; histamine secretion by mast cell; vesicle targeting; post-Golgi vesicle-mediated transport; synaptic vesicle priming |
NCBI Summary: | Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00161 |
NCBI GenInfo Identifier: | 6685971 |
NCBI Gene ID: | 8773 |
NCBI Accession: | O00161.1 |
UniProt Secondary Accession: | O00161,O00162, Q13602, Q6IAE3, |
UniProt Related Accession: | O00161 |
Molecular Weight: | 17,789 Da |
NCBI Full Name: | Synaptosomal-associated protein 23 |
NCBI Synonym Full Names: | synaptosomal-associated protein, 23kDa |
NCBI Official Symbol: | SNAP23Â Â |
NCBI Official Synonym Symbols: | SNAP-23; SNAP23A; SNAP23B; HsT17016Â Â |
NCBI Protein Information: | synaptosomal-associated protein 23; synaptosomal-associated protein, 23kD; vesicle-membrane fusion protein SNAP-23 |
UniProt Protein Name: | Synaptosomal-associated protein 23 |
UniProt Synonym Protein Names: | Vesicle-membrane fusion protein SNAP-23 |
Protein Family: | Synaptosomal-associated protein |
UniProt Gene Name: | SNAP23Â Â |
UniProt Entry Name: | SNP23_HUMAN |