Anti-SELPLG Antibody (RACO0473)
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주문- SKU:
- RACO0473
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Product Name: | SELPLG Antibody |
Product SKU: | RACO0473 |
Size: | 50ul |
Host Species: | Homo sapiens (Human) |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | A synthesized peptide derived from human CD162 |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. |
Synonyms: | P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162), SELPLG |
IHC image of RACO0473 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
UniProt Protein Function: | SELPLG: A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12q24 Cellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane Molecular Function:protein binding; receptor binding Biological Process: leukocyte tethering or rolling; cell adhesion; blood coagulation; leukocyte adhesive activation; leukocyte migration |
NCBI Summary: | This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011] |
UniProt Code: | Q14242 |
NCBI GenInfo Identifier: | 2498904 |
NCBI Gene ID: | 6404 |
NCBI Accession: | Q14242.1 |
UniProt Secondary Accession: | Q14242,Q12775, Q6GTW7, Q8N7J7, A8K2Y0, B4DQC3, B7Z5C7 J3KMX6, |
UniProt Related Accession: | Q14242 |
Molecular Weight: | 412 |
NCBI Full Name: | P-selectin glycoprotein ligand 1 |
NCBI Synonym Full Names: | selectin P ligand |
NCBI Official Symbol: | SELPLGÂ Â |
NCBI Official Synonym Symbols: | CLA; CD162; PSGL1; PSGL-1Â Â |
NCBI Protein Information: | P-selectin glycoprotein ligand 1; cutaneous lymphocyte-associated associated antigen |
UniProt Protein Name: | P-selectin glycoprotein ligand 1 |
UniProt Synonym Protein Names: | Selectin P ligand; CD_antigen: CD162 |
Protein Family: | P-selectin glycoprotein ligand |
UniProt Gene Name: | SELPLGÂ Â |
UniProt Entry Name: | SELPL_HUMAN |