Anti-PTPRN Antibody (CAB16421)
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주문- SKU:
- CAB16421
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Antibody Name: | Anti-PTPRN Antibody |
Antibody SKU: | CAB16421 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant protein of human PTPRN |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Reactivity: | Mouse, Rat |
Positive Samples: |
Immunogen: | Recombinant protein of human PTPRN |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 5798 |
Uniprot: | Q16849 |
Cellular Location: | Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane, Perikaryon, Single-pass type I membrane protein, axon, secretory vesicle membrane, synapse |
Calculated MW: | 96kDa/102kDa/105kDa |
Observed MW: | Refer to figures |
Synonyms: | PTPRN, IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N |
Background: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants. |
UniProt Protein Function: | PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q35-q36.1 Cellular Component: integral to membrane Molecular Function:GTPase binding; protein binding; spectrin binding; protein tyrosine phosphatase activity Biological Process: response to reactive oxygen species; response to cAMP; response to estrogen stimulus; insulin secretion; cytokine and chemokine mediated signaling pathway; response to glucose stimulus; protein amino acid dephosphorylation; response to insulin stimulus |
NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] |
UniProt Code: | Q16849 |
NCBI GenInfo Identifier: | 2499754 |
NCBI Gene ID: | 5798 |
NCBI Accession: | Q16849.1 |
UniProt Secondary Accession: | Q16849,Q08319, Q53QD6, Q6NSL1, B4DK12, F5GZS3, |
UniProt Related Accession: | Q16849 |
Molecular Weight: | 979 |
NCBI Full Name: | Receptor-type tyrosine-protein phosphatase-like N |
NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type, N |
NCBI Official Symbol: | PTPRN |
NCBI Official Synonym Symbols: | IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP |
NCBI Protein Information: | receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N |
UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase-like N |
UniProt Synonym Protein Names: | Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2 |
Protein Family: | Receptor-type tyrosine-protein phosphatase |
UniProt Gene Name: | PTPRN |
UniProt Entry Name: | PTPRN_HUMAN |
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