Anti-Phospho-PPP2CA (Y307) Antibody (RACO0062)
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주문- SKU:
- RACO0062
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Conjugation:
- Unconjugated
Description
Product Name: | Phospho-PPP2CA (Y307) Antibody |
Product SKU: | RACO0062 |
Size: | 50ul |
Host Species: | Human |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:5000 |
Species Reactivity: | Human |
Immunogen: | A synthesized peptide derived from human Phospho-PPP2CA (Y307) |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. |
Synonyms: | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, Replication protein C, RP-C, PPP2CA |
Western Blot. Positive WB detected in A549 whole cell lysate treated with EGF or not). All lanes Phospho-PPP2CA antibody at 0.95µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 35 KDa. Observed band size: 35 KDa. |
UniProt Protein Function: | PPP2CA: ubiquitous cytosolic Ser/Thr protein phosphatase, catalytic subunit. The holoenzyme consists of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B'/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. |
UniProt Protein Details: | Protein type:EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: microtubule cytoskeleton; spindle pole; protein phosphatase type 2A complex; membrane; mitochondrion; plasma membrane; nucleus; cytosol; chromosome, pericentric region Molecular Function:protein dimerization activity; protein C-terminus binding; protein binding; metal ion binding; GABA receptor binding; protein serine/threonine phosphatase activity Biological Process: mitotic nuclear envelope reassembly; apoptosis; regulation of protein amino acid autophosphorylation; protein amino acid dephosphorylation; response to organic substance; regulation of transcription, DNA-dependent; meiotic cell cycle; regulation of cell differentiation; regulation of growth; mesoderm development; regulation of receptor activity; regulation of DNA replication; inactivation of MAPK activity; second-messenger-mediated signaling; regulation of cell adhesion; fibroblast growth factor receptor signaling pathway; RNA splicing; regulation of Wnt receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat3 protein; mRNA catabolic process, nonsense-mediated decay; gene expression; regulation of protein catabolic process; mitotic cell cycle; negative regulation of cell growth; ceramide metabolic process |
NCBI Summary: | This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008] |
UniProt Code: | P67775 |
NCBI GenInfo Identifier: | 54038809 |
NCBI Gene ID: | 5515 |
NCBI Accession: | P67775.1 |
UniProt Related Accession: | P67775 |
Molecular Weight: | |
NCBI Full Name: | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
NCBI Synonym Full Names: | protein phosphatase 2 catalytic subunit alpha |
NCBI Official Symbol: | PPP2CAÂ Â |
NCBI Official Synonym Symbols: | RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha  |
NCBI Protein Information: | serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
UniProt Protein Name: | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
UniProt Synonym Protein Names: | Replication protein C |
Protein Family: | PP2A regulatory |
UniProt Gene Name: | PPP2CAÂ Â |
UniProt Entry Name: | PP2AA_HUMAN |