Anti-PDCD1 Antibody (RACO0351)
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주문- SKU:
- RACO0351
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Product Name: | PDCD1 Antibody |
Product SKU: | RACO0351 |
Size: | 50ul |
Host Species: | Homo sapiens (Human) |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | A synthesized peptide derived from human PD1 |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors. |
Synonyms: | Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279), PDCD1, PD1 |
IHC image of RACO0351 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. | |
Western Blot. Positive WB detected in MCF-7 whole cell lysate All lanes PD1 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 32 KDa. Observed band size: 32 kDa. |
UniProt Protein Function: | Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors. |
NCBI Summary: | This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15116 |
NCBI GenInfo Identifier: | 145559515 |
NCBI Gene ID: | 5133 |
NCBI Accession: | Q15116.3 |
UniProt Secondary Accession: | Q15116,Q02242, |
UniProt Related Accession: | Q15116 |
Molecular Weight: | |
NCBI Full Name: | Programmed cell death protein 1 |
NCBI Synonym Full Names: | programmed cell death 1 |
NCBI Official Symbol: | PDCD1Â Â |
NCBI Official Synonym Symbols: | PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1Â Â |
NCBI Protein Information: | programmed cell death protein 1 |
UniProt Protein Name: | Programmed cell death protein 1 |
UniProt Synonym Protein Names: | CD_antigen: CD279 |
UniProt Gene Name: | PDCD1Â Â |