Anti-OPRD1 Antibody (RACO0265)
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주문- SKU:
- RACO0265
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Conjugation:
- Unconjugated
Description
Product Name: | OPRD1 Antibody |
Product SKU: | RACO0265 |
Size: | 50ul |
Host Species: | Homo sapiens (Human) |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:5000 |
Species Reactivity: | Human, Mouse |
Immunogen: | A synthesized peptide derived from human OPRD1 |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. |
Synonyms: | Delta-type opioid receptor (D-OR-1) (DOR-1), OPRD1, OPRD |
Western Blot. Positive WB detected in SH-SY5Y whole cell lysate 293 whole cell lysate Hela whole cell lysate U251 whole cell lysate A549 whole cell lysate Mouse brain tissue. All lanes OPRD1 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 41 kDa. Observed band size: 41 kDa. |
UniProt Protein Function: | DOR-1: delta opioid receptor, a G-protein coupled receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. Receptor for enkephalins. |
UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p36.1-p34.3 Cellular Component: cytoplasm; integral to plasma membrane; intrinsic to plasma membrane; lipid raft; nerve terminal; neuron projection; plasma membrane; postsynaptic membrane; vesicle Molecular Function:neuropeptide binding; opioid receptor activity; protein binding Biological Process: activation of CREB transcription factor; adult locomotory behavior; eating behavior; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; negative regulation of protein oligomerization; neuropeptide signaling pathway; positive regulation of peptidyl-serine phosphorylation; protein import into nucleus, translocation; regulation of calcium ion transport; regulation of mitochondrial membrane potential; regulation of sensory perception of pain; synaptic transmission |
UniProt Code: | P41143 |
NCBI GenInfo Identifier: | 311033488 |
NCBI Gene ID: | 4985 |
NCBI Accession: | P41143.4 |
UniProt Secondary Accession: | P41143,B5B0B8, |
UniProt Related Accession: | P41143 |
Molecular Weight: | 40,369 Da |
NCBI Full Name: | Delta-type opioid receptor |
NCBI Synonym Full Names: | opioid receptor delta 1 |
NCBI Official Symbol: | OPRD1Â Â |
NCBI Official Synonym Symbols: | OPRDÂ Â |
NCBI Protein Information: | delta-type opioid receptor |
UniProt Protein Name: | Delta-type opioid receptor |
Protein Family: | Delta-type opioid receptor |
UniProt Gene Name: | OPRD1Â Â |
UniProt Entry Name: | OPRD_HUMAN |