Anti-NR2F1 Antibody (CAB16437)
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주문- SKU:
- CAB16437
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Antibody Name: | Anti-NR2F1 Antibody |
Antibody SKU: | CAB16437 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF |
Reactivity: | Human, Rat |
Host Species: | Rabbit |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human NR2F1 (NP_005645.1). |
Application: | WB IF |
Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
Reactivity: | Human, Rat |
Positive Samples: |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human NR2F1 (NP_005645.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | QFTC EGCK SFFK RSVR RNLT YTCR ANRN CPID QHHR NQCQ YCRL KKCL KVGM RREA VQRG RMPP TQPN PGQY ALTN GDPL NGHC YLSG YISL LLRA EPYP T |
Gene ID: | 7025 |
Uniprot: | P10589 |
Cellular Location: | Nucleus |
Calculated MW: | 46kDa |
Observed MW: | Refer to figures |
Synonyms: | NR2F1, BBOAS, BBSOAS, COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1 |
Background: | The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). |
UniProt Protein Function: | NR2F1: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. Binds DNA as dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2. Inhibited by gonadotropin in granulosa cells. Belongs to the nuclear hormone receptor family. NR2 subfamily. |
UniProt Protein Details: | Protein type:DNA-binding; Nuclear receptor; Transcription factor Chromosomal Location of Human Ortholog: 5q14 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity Biological Process: negative regulation of transcription from RNA polymerase II promoter; signal transduction; transcription initiation from RNA polymerase II promoter Disease: Bosch-boonstra-schaaf Optic Atrophy Syndrome |
NCBI Summary: | The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014] |
UniProt Code: | P10589 |
NCBI GenInfo Identifier: | 116959 |
NCBI Gene ID: | 7025 |
NCBI Accession: | P10589.1 |
UniProt Related Accession: | P10589 |
Molecular Weight: | 46,156 Da |
NCBI Full Name: | COUP transcription factor 1 |
NCBI Synonym Full Names: | nuclear receptor subfamily 2 group F member 1 |
NCBI Official Symbol: | NR2F1 |
NCBI Official Synonym Symbols: | EAR3; BBOAS; EAR-3; NR2F2; SVP44; BBSOAS; ERBAL3; TFCOUP1; COUP-TFI; TCFCOUP1 |
NCBI Protein Information: | COUP transcription factor 1 |
UniProt Protein Name: | COUP transcription factor 1 |
UniProt Synonym Protein Names: | COUP transcription factor I; COUP-TF I; Nuclear receptor subfamily 2 group F member 1; V-erbA-related protein 3; EAR-3 |
Protein Family: | COUP transcription factor |
UniProt Gene Name: | NR2F1 |
UniProt Entry Name: | COT1_HUMAN |
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