Anti-NLRC4 Antibody (CAB13117)
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주문- SKU:
- CAB13117
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Antibody Name: | Anti-NLRC4 Antibody |
Antibody SKU: | CAB13117 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC IF |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 89-159 of mouse NLRC4 (NP_001028539.1). |
Application: | WB IHC IF |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse |
Positive Samples: | U-87MG, 293T, Mouse kidney |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 89-159 of mouse NLRC4 (NP_001028539.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | LSYQ VTEE DLNV LAQN LKDL YNSP AFLN FYPL GEDI DIIF NLEK TFTE PIMW KKDH RHHR VEQL TLGS LLE |
Gene ID: | 268973 |
Uniprot: | Q9NPP4 |
Cellular Location: | Cytoplasm, cytosol |
Calculated MW: | 116kDa |
Observed MW: | 102kDa |
Synonyms: | NLRC4, AIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4, IPAF |
Background: | This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | NLRC4: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 2p22.3 Cellular Component: cytosol; nucleus; spindle microtubule Molecular Function:ATP binding; cysteine protease inhibitor activity; identical protein binding; magnesium ion binding; protein binding; protein homodimerization activity; ubiquitin-protein ligase activity Biological Process: activation of innate immune response; activation of NF-kappaB transcription factor; caspase activation; defense response to bacterium; detection of bacterium; inflammatory response; innate immune response; interleukin-1 beta secretion; positive regulation of apoptosis; protein homooligomerization; regulation of apoptosis; regulation of signal transduction Disease: Autoinflammation With Infantile Enterocolitis; Familial Cold Autoinflammatory Syndrome 4 |
NCBI Summary: | This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
UniProt Code: | Q9NPP4 |
NCBI GenInfo Identifier: | 20138032 |
NCBI Gene ID: | 58484 |
NCBI Accession: | Q9NPP4.2 |
UniProt Secondary Accession: | Q9NPP4,Q96J81, Q96J82, Q96J83, A8K9F8, B2RBQ3, B3KTF0 D6W580, |
UniProt Related Accession: | Q9NPP4 |
Molecular Weight: | 10,646 Da |
NCBI Full Name: | NLR family CARD domain-containing protein 4 |
NCBI Synonym Full Names: | NLR family CARD domain containing 4 |
NCBI Official Symbol: | NLRC4 |
NCBI Official Synonym Symbols: | CLAN; IPAF; AIFEC; CLAN1; CLANA; CLANB; CLANC; CLAND; FCAS4; CARD12; CLR2.1 |
NCBI Protein Information: | NLR family CARD domain-containing protein 4 |
UniProt Protein Name: | NLR family CARD domain-containing protein 4 |
UniProt Synonym Protein Names: | CARD, LRR, and NACHT-containing protein; Clan protein; Caspase recruitment domain-containing protein 12; Ice protease-activating factor; Ipaf |
Protein Family: | NLR family CARD domain-containing protein |
UniProt Gene Name: | NLRC4 |
UniProt Entry Name: | NLRC4_HUMAN |