Anti-Methyl-RBBP7-H96 Antibody (CAB18819)

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SKU:
CAB18819
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
RBBP7
Synonyms:
RbAp46
Synonyms:
histone-binding protein RBBP7
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Description

Product Name:Methyl-RBBP7-H96 Rabbit pAb
Product Code:CAB18819
Size:20uL, 50uL, 100uL
Synonyms:RBBP7, RbAp46, histone-binding protein RBBP7
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human Methyl-RBBP7-H96, 3-methyl (tau-methyl).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A synthetic peptide of human Methyl-RBBP7-H96, 3-methyl (tau-methyl).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5931
Uniprot:Q16576
Cellular Location:Nucleus
Calculated MW:47kDa/52kDa
Observed MW:Refer to figures
UniProt Protein Function:RBBP7: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein- binding domain of the retinoblastoma protein (RB1). Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Interacts with BRCA1, HDAC7 and SUV39H1. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: ESC/E(Z) complex; nucleoplasm; nucleus; NuRD complex

Molecular Function:histone deacetylase activity; protein binding

Biological Process: cell proliferation; DNA replication-independent nucleosome assembly at centromere; multicellular organismal development; negative regulation of cell growth; negative regulation of gene expression, epigenetic

NCBI Summary:This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Code:Q16576
NCBI GenInfo Identifier:2494891
NCBI Gene ID:5931
NCBI Accession:Q16576.1
UniProt Secondary Accession:Q16576,Q5JP00,
UniProt Related Accession:Q16576
Molecular Weight:52,314 Da
NCBI Full Name:Histone-binding protein RBBP7
NCBI Synonym Full Names:RB binding protein 7, chromatin remodeling factor
NCBI Official Symbol:RBBP7  
NCBI Official Synonym Symbols:RbAp46  
NCBI Protein Information:histone-binding protein RBBP7
UniProt Protein Name:Histone-binding protein RBBP7
UniProt Synonym Protein Names:Histone acetyltransferase type B subunit 2; Nucleosome-remodeling factor subunit RBAP46; Retinoblastoma-binding protein 7; RBBP-7; Retinoblastoma-binding protein p46
Protein Family:Histone-binding protein
UniProt Gene Name:RBBP7  
UniProt Entry Name:RBBP7_HUMAN
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