Anti-LYPLA1 Antibody (CAB4419)

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SKU:
CAB4419
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
LYPLA1
Synonyms:
APT-1
Synonyms:
APT1
Synonyms:
LPL-I
Synonyms:
LPL1
Synonyms:
hAPT1
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Description

Product Name:LYPLA1 Rabbit pAb
Product Code:CAB4419
Size:20uL, 50uL, 100uL
Synonyms:LYPLA1, APT-1, APT1, LPL-I, LPL1, hAPT1
Applications:WB, IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human LYPLA1 (NP_006321.1).
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:LO2, Mouse heart, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human LYPLA1 (NP_006321.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MCGN NMST PLPA IVPA ARKA TAAV IFLH GLGD TGHG WAEA FAGI RSSH IKYI CPHA PVRP VTLN MNVA MPSW FDII GLSP DSQE DESG IKQA AENI KALI DQEV KNGI PSNR IILG GFSQ GGAL SLYT ALTT QQKL AGVT ALSC WLPL RASF PQGP IGGA NRDI SILQ CHGD CDPL VPLM FGSL TVEK LKTL VNPA NVTF KTYE GMMH SSCQ QEMM DVKQ FIDK LLPP ID
Gene ID:10434
Uniprot:O75608
Cellular Location:Cytoplasm
Calculated MW:22kDa/24kDa
Observed MW:25kDa
UniProt Protein Function:LYPLA1: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity. Belongs to the AB hydrolase 2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Lipid Metabolism - glycerophospholipid; Phospholipase; EC 3.1.2.-

Chromosomal Location of Human Ortholog: 8q11.23

Cellular Component: cytoplasm; cytosol

Molecular Function:lipase activity; lysophospholipase activity; palmitoyl-(protein) hydrolase activity

Biological Process: protein depalmitoylation; regulation of nitric-oxide synthase activity

NCBI Summary:This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]
UniProt Code:O75608
NCBI GenInfo Identifier:41017274
NCBI Gene ID:10434
NCBI Accession:O75608.1
UniProt Secondary Accession:O75608,O43202, Q9UQF9,
UniProt Related Accession:O75608
Molecular Weight:22,875 Da
NCBI Full Name:Acyl-protein thioesterase 1
NCBI Synonym Full Names:lysophospholipase I
NCBI Official Symbol:LYPLA1  
NCBI Official Synonym Symbols:APT1; LPL1; APT-1; LPL-I; hAPT1  
NCBI Protein Information:acyl-protein thioesterase 1
UniProt Protein Name:Acyl-protein thioesterase 1
UniProt Synonym Protein Names:Lysophospholipase 1; Lysophospholipase I; LPL-I; LysoPLA I
UniProt Gene Name:LYPLA1  
UniProt Entry Name:LYPA1_HUMAN
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