Anti-LTA4H Antibody (RACO0577)
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주문- SKU:
- RACO0577
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Product Name: | LTA4H Antibody |
Product SKU: | RACO0577 |
Size: | 50ul |
Host Species: | Homo sapiens (Human) |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:5000 |
Species Reactivity: | Human, Mouse |
Immunogen: | A synthesized peptide derived from human LTA4H |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. |
Synonyms: | Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase), LTA4H, LTA4 |
Western Blot. Positive WB detected in Hela whole cell lysate 293 whole cell lysate 293T whole cell lysate PC-3 whole cell lysate Mouse Brain whole cell lysate All lanes LTA4h) antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 70, 60, 58, 67 kDa. Observed band size: 70 kDa. |
UniProt Protein Function: | LTA4H: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. Belongs to the peptidase M1 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.3.2.6; Hydrolase; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 12q22 Cellular Component: nucleoplasm; cytoplasm; cytosol Molecular Function:peptidase activity; leukotriene-A4 hydrolase activity; metallopeptidase activity; zinc ion binding; epoxide hydrolase activity; aminopeptidase activity Biological Process: leukotriene biosynthetic process; peptide catabolic process; arachidonic acid metabolic process; leukotriene metabolic process; proteolysis; inflammatory response |
NCBI Summary: | The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] |
UniProt Code: | P09960 |
NCBI GenInfo Identifier: | 126353 |
NCBI Gene ID: | 4048 |
NCBI Accession: | P09960.2 |
UniProt Related Accession: | P09960 |
Molecular Weight: | ~ 69kDa |
NCBI Full Name: | Leukotriene A-4 hydrolase |
NCBI Synonym Full Names: | leukotriene A4 hydrolase |
NCBI Official Symbol: | LTA4HÂ Â |
NCBI Protein Information: | leukotriene A-4 hydrolase |
UniProt Protein Name: | Leukotriene A-4 hydrolase |
UniProt Synonym Protein Names: | Leukotriene A(4) hydrolase |
Protein Family: | Leukotriene A-4 hydrolase |
UniProt Gene Name: | LTA4HÂ Â |
UniProt Entry Name: | LKHA4_HUMAN |