Anti-LPCAT1 Antibody (CAB4987)

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SKU:
CAB4987
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
LPCAT1
Synonyms:
AGPAT10
Synonyms:
AGPAT9
Synonyms:
AYTL2
Synonyms:
LPCAT-1
Synonyms:
PFAAP3
Synonyms:
lpcat
Synonyms:
lysoPAFAT
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Description

Product Name:LPCAT1 Rabbit pAb
Product Code:CAB4987
Size:20uL, 50uL, 100uL
Synonyms:LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 325-534 of human LPCAT1 (NP_079106.3).
Applications:WB, IHC
Recommended Dilutions:WB 1:1000 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:BT-474, 22Rv1, Hela, A-549, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 325-534 of human LPCAT1 (NP_079106.3).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LPAD TCLL EFAR LVRG LGLK PEKL EKDL DRYS ERAR MKGG EKIG IAEF AASL EVPV SDLL EDMF SLFD ESGS GEVD LREC VVAL SVVC RPAR TLDT IQLA FKMY GAQE DGSV GEGD LSCI LKTA LGVA ELTV TDLF RAID QEEK GKIT FADF HRFA EMYP AFAE EYLY PDQT HFES CAET SPAP IPNG FCAD FSPE NSDA GRKP VRKK LD
Gene ID:79888
Uniprot:Q8NF37
Cellular Location:Endoplasmic reticulum membrane, Golgi apparatus membrane, Lipid droplet, Single-pass type II membrane protein
Calculated MW:59kDa
Observed MW:59kDa
UniProt Protein Function:LPCAT1: Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
UniProt Protein Details:

Protein type:EC 2.3.1.67; Acetyltransferase; Membrane protein, integral; EC 2.3.1.23; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane; lipid particle

Molecular Function:1-alkylglycerophosphocholine O-acetyltransferase activity; 1-acylglycerophosphocholine O-acyltransferase activity; 1-alkenylglycerophosphocholine O-acyltransferase activity; 1-alkylglycerophosphocholine O-acyltransferase activity; calcium ion binding

Biological Process: retina development in camera-type eye; phospholipid metabolic process; glycerophospholipid biosynthetic process; positive regulation of protein catabolic process; phosphatidic acid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; surfactant homeostasis; phospholipid biosynthetic process

NCBI Summary:Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis (Nakanishi et al., 2006 [PubMed 16704971]).[supplied by OMIM, May 2008]
UniProt Code:Q8NF37
NCBI GenInfo Identifier:110815902
NCBI Gene ID:79888
NCBI Accession:Q8NF37.2
UniProt Secondary Accession:Q8NF37,Q1HAQ1, Q7Z4G6, Q8N3U7, Q8WUL8, Q9GZW6,
UniProt Related Accession:Q8NF37
Molecular Weight:Calculated MW: 59kDaObserved MW:59kDa
NCBI Full Name:Lysophosphatidylcholine acyltransferase 1
NCBI Synonym Full Names:lysophosphatidylcholine acyltransferase 1
NCBI Official Symbol:LPCAT1  
NCBI Official Synonym Symbols:AYTL2; lpcat; PFAAP3  
NCBI Protein Information:lysophosphatidylcholine acyltransferase 1; LPCAT-1; lysoPAFAT; LPC acyltransferase 1; acyltransferase like 2; acyltransferase-like 2; lysoPC acyltransferase 1; lyso-PAF acetyltransferase; regulated by phosphonoformate; acetyl-CoA:lyso-PAF acetyltransferase; phosphonoformate immuno-associated protein 3; 1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; acyl-CoA:lysophosphatidylcholine acyltransferase 1; acetyl-CoA:lyso-platelet-activating factor acetyltransferase
UniProt Protein Name:Lysophosphatidylcholine acyltransferase 1
UniProt Synonym Protein Names:1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67); Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acetyl-CoA:lyso-PAF acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT; Acyltransferase-like 2; Phosphonoformate immuno-associated protein 3
Protein Family:Lysophosphatidylcholine acyltransferase
UniProt Gene Name:LPCAT1  
UniProt Entry Name:PCAT1_HUMAN
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