Anti-IGFBP2 Antibody (RACO0425)
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주문- SKU:
- RACO0425
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Description
Product Name: | IGFBP2 Antibody |
Product SKU: | RACO0425 |
Size: | 50ul |
Host Species: | Homo sapiens (Human) |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | A synthesized peptide derived from human IGFBP2 |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |
Synonyms: | Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2), IGFBP2, BP2 IBP2 |
IHC image of RACO0425 diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. | |
Western Blot. Positive WB detected in MCF-7 whole cell lysate All lanes IGFBP2 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 35 kDa. Observed band size: 35 kDa. |
UniProt Protein Function: | IGFBP2: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Binds IGF2 more than IGF1. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2q35 Cellular Component: extracellular space; apical plasma membrane; extracellular region; cytoplasmic vesicle Molecular Function:protein binding; insulin-like growth factor I binding; insulin-like growth factor II binding Biological Process: response to drug; regulation of insulin-like growth factor receptor signaling pathway; response to retinoic acid; response to lithium ion; response to glucocorticoid stimulus; female pregnancy; positive regulation of activated T cell proliferation; signal transduction; response to estradiol stimulus; cellular response to hormone stimulus; cellular protein metabolic process; response to mechanical stimulus; regulation of cell growth; response to nutrient; aging |
UniProt Code: | P18065 |
NCBI GenInfo Identifier: | 290457647 |
NCBI Gene ID: | 3485 |
NCBI Accession: | P18065.2 |
UniProt Secondary Accession: | P18065,Q14619, Q9UCL3, |
UniProt Related Accession: | P18065 |
Molecular Weight: | 34,814 Da |
NCBI Full Name: | Insulin-like growth factor-binding protein 2 |
NCBI Synonym Full Names: | insulin-like growth factor binding protein 2, 36kDa |
NCBI Official Symbol: | IGFBP2Â Â |
NCBI Official Synonym Symbols: | IBP2; IGF-BP53Â Â |
NCBI Protein Information: | insulin-like growth factor-binding protein 2; IBP-2; IGFBP-2; IGF-binding protein 2 |
UniProt Protein Name: | Insulin-like growth factor-binding protein 2 |
Protein Family: | Insulin-like growth factor-binding protein |
UniProt Gene Name: | IGFBP2Â Â |
UniProt Entry Name: | IBP2_HUMAN |