Anti-IGF2 Antibody (RACO0202)
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주문- SKU:
- RACO0202
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Product Name: | IGF2 Antibody |
Product SKU: | RACO0202 |
Size: | 50ul |
Host Species: | Human |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Human |
Immunogen: | A synthesized peptide derived from human IGF2 |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). |
Synonyms: | Insulin-like growth factor II, IGF-II, Somatomedin-A, T3M-11-derived growth factor, Insulin-like growth factor II, Insulin-like growth factor II Ala-25 Del, Preptin, IGF2, PP1446 |
NCBI Summary: | This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
UniProt Code: | P01344 |
NCBI GenInfo Identifier: | 124255 |
NCBI Gene ID: | 3481 |
NCBI Accession: | P01344.1 |
UniProt Related Accession: | P01344 |
Molecular Weight: | 11kDa |
NCBI Full Name: | Insulin-like growth factor II |
NCBI Synonym Full Names: | insulin like growth factor 2 |
NCBI Official Symbol: | IGF2Â Â |
NCBI Official Synonym Symbols: | GRDF; IGF-II; PP9974; C11orf43Â Â |
NCBI Protein Information: | insulin-like growth factor II |
UniProt Protein Name: | Insulin-like growth factor II |
UniProt Synonym Protein Names: | Somatomedin-ACleaved into the following 3 chains:Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin |
Protein Family: | Insulin-like growth factor |
UniProt Gene Name: | IGF2Â Â |
UniProt Entry Name: | IGF2_HUMAN |