Anti-HMGN3 Antibody (CAB12649)
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주문- SKU:
- CAB12649
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Antibody Name: | Anti-HMGN3 Antibody |
Antibody SKU: | CAB12649 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-77 of human HMGN3 (NP_620058.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Mouse |
Positive Samples: | Mouse kidney |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-77 of human HMGN3 (NP_620058.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MPKR KSPE NTEG KDGS KVTK QEPT RRSA RLSA KPAP PKPE PKPR KTSA KKEP GAKI SRGA KGKK EEKQ EAGK EGTE N |
Gene ID: | 9324 |
Uniprot: | Q15651 |
Cellular Location: | Nucleus |
Calculated MW: | 8kDa/10kDa |
Observed MW: | 12kDa |
Synonyms: | HMGN3, PNAS-24, PNAS-25, TRIP7 |
Background: | The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. |
UniProt Protein Function: | HMGN3: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. Belongs to the HMGN family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 6q14.1 Cellular Component: cytoplasm; nucleoplasm |
NCBI Summary: | The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016] |
UniProt Code: | Q15651 |
NCBI GenInfo Identifier: | 23831169 |
NCBI Gene ID: | 9324 |
NCBI Accession: | Q15651.2 |
UniProt Secondary Accession: | Q15651,Q5HYD3, Q7RTT0, Q969M5, Q9BZT7, B2RD37, |
UniProt Related Accession: | Q15651 |
Molecular Weight: | 8,378 Da |
NCBI Full Name: | High mobility group nucleosome-binding domain-containing protein 3 |
NCBI Synonym Full Names: | high mobility group nucleosomal binding domain 3 |
NCBI Official Symbol: | HMGN3 |
NCBI Official Synonym Symbols: | TRIP7; PNAS-24; PNAS-25 |
NCBI Protein Information: | high mobility group nucleosome-binding domain-containing protein 3 |
UniProt Protein Name: | High mobility group nucleosome-binding domain-containing protein 3 |
UniProt Synonym Protein Names: | Thyroid receptor-interacting protein 7; TR-interacting protein 7; TRIP-7 |
Protein Family: | High mobility group nucleosome-binding domain-containing protein |
UniProt Gene Name: | HMGN3 |
UniProt Entry Name: | HMGN3_HUMAN |
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