Anti-GFAP Antibody (MACO0603)
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주문- SKU:
- MACO0603
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Mouse
- Isotype:
- IgG2b
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Application:
- FC
- Antibody type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Product Name: | Anti-GFAP Antibody |
Product Sku: | MACO0603 |
Size: | 50ul |
Host Species: | Mouse |
Tested Applications: | ELISA, WB, IHC, IF, FC |
Recommended Dilutions: | WB:1:500-1:5000, IHC:1:50-1:500, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Recombinant Human GFAP protein (292-432AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Monoclonal |
Isotype: | IgG2b |
Conjugate: | Non-conjugated |
Background: | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
Synonyms: | Glial fibrillary acidic protein, GFAP |
Immunohistochemistry of paraffin-embedded human brain tissue using MACO0603 at dilution of 1:100 | |
Immunohistochemistry of paraffin-embedded human glioma using MACO0603 at dilution of 1:100 | |
Western Blot Positive WB detected in: Mouse brain tissue, Rat brain tissue All lanes: GFAP antibody at 2.7µg/ml Secondary Goat polyclonal to Mouse IgG at 1/10000 dilution Predicted band size: 50, 51 kDa Observed band size: 50 kDa |
UniProt Protein Function: | GFAP: a class-III intermediate filament protein. A cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant isoform has been described, but its full length sequence has not been determined. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 17q21 Cellular Component: membrane; cytoplasm; intermediate filament; cytosol Molecular Function:integrin binding; structural constituent of cytoskeleton; kinase binding Biological Process: Bergmann glial cell differentiation; extracellular matrix organization and biogenesis; regulation of neurotransmitter uptake; response to wounding; intermediate filament organization; neurite regeneration; astrocyte development Disease: Alexander Disease |
NCBI Summary: | This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] |
UniProt Code: | P14136 |
NCBI GenInfo Identifier: | 121135 |
NCBI Gene ID: | 2670 |
NCBI Accession: | P14136.1 |
UniProt Secondary Accession: | P14136,Q53H98, Q5D055, Q6ZQS3, Q7Z5J6, Q7Z5J7, Q96KS4 Q96P18, Q9UFD0, B2RD44, D3DX59, E9PAX3, |
UniProt Related Accession: | P14136 |
Molecular Weight: | 432 |
NCBI Full Name: | Glial fibrillary acidic protein |
NCBI Synonym Full Names: | glial fibrillary acidic protein |
NCBI Official Symbol: | GFAPÂ Â |
NCBI Protein Information: | glial fibrillary acidic protein |
UniProt Protein Name: | Glial fibrillary acidic protein |
Protein Family: | Glial fibrillary acidic protein |
UniProt Gene Name: | GFAPÂ Â |
UniProt Entry Name: | GFAP_HUMAN |