Anti-ECH1 Antibody (CAB19868)[KO Validated]
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주문- SKU:
- CAB19868
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
Antibody Name: | Anti-ECH1 Antibody [KO Validated] |
Antibody SKU: | CAB19868 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant protein of human ECH1. |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | 293T |
Immunogen: | Recombinant protein of human ECH1. |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 1891 |
Uniprot: | Q13011 |
Cellular Location: | Mitochondrion, Peroxisome |
Calculated MW: | 35kDa |
Observed MW: | 32KDa |
Synonyms: | ECH1, HPXEL |
Background: | This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans, 5-cis-dienoyl-CoA to 2-trans, 4-trans-dienoyl-CoA, indicating that it is a delta3, 5-delta2, 4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. |
UniProt Protein Function: | ECH1: Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4- trans-dienoyl-CoA. Belongs to the enoyl-CoA hydratase/isomerase family. |
UniProt Protein Details: | Protein type:Mitochondrial; Isomerase; Amino Acid Metabolism - tyrosine; EC 5.3.3.- Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: membrane Molecular Function:protein binding; receptor binding |
NCBI Summary: | This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13011 |
NCBI GenInfo Identifier: | 82654933 |
NCBI Gene ID: | 1891 |
NCBI Accession: | Q13011.2 |
UniProt Secondary Accession: | Q13011,Q8WVX0, Q96EZ9, A8K745, |
UniProt Related Accession: | Q13011 |
Molecular Weight: | 35,816 Da |
NCBI Full Name: | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial |
NCBI Synonym Full Names: | enoyl-CoA hydratase 1 |
NCBI Official Symbol: | ECH1 |
NCBI Official Synonym Symbols: | HPXEL |
NCBI Protein Information: | delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial |
UniProt Protein Name: | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial |
UniProt Gene Name: | ECH1 |
UniProt Entry Name: | ECH1_HUMAN |