Anti-DNAJC2 Antibody (CAB4633)

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주문
SKU:
CAB4633
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
DNAJC2
Synonyms:
MPHOSPH11
Synonyms:
MPP11
Synonyms:
ZRF1
Synonyms:
ZUO1
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Description

Product Name:DNAJC2 Rabbit pAb
Product Code:CAB4633
Size:20uL, 50uL, 100uL
Synonyms:DNAJC2, MPHOSPH11, MPP11, ZRF1, ZUO1
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human DNAJC2 (NP_055192.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Jurkat, MCF7, HeLa, A-549, Mouse testis, Mouse spleen, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human DNAJC2 (NP_055192.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLLL PSAA DGRG TAIT HALT SAST LCQV EPVG RWFE AFVK RRNR NASA SFQE LEDK KELS EESE DEEL QLEE FPML KTLD PKDW KNQD HYAV LGLG HVRY KATQ RQIK AAHK AMVL KHHP DKRK AAGE PIKE GDND YFTC
Gene ID:27000
Uniprot:Q99543
Cellular Location:Cytoplasm, Nucleus, cytosol
Calculated MW:65kDa/71kDa
Observed MW:72kDa
UniProt Protein Function:DNAJC2: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA replication; Chaperone; Cell cycle regulation

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: nuclear membrane; cytoplasm; cytosol; nucleus

Molecular Function:ubiquitin binding; DNA binding; histone binding; Hsp70 protein binding; chromatin binding

Biological Process: 'de novo' cotranslational protein folding; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of cell growth; chromatin modification; DNA replication

NCBI Summary:This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q99543
NCBI GenInfo Identifier:296439472
NCBI Gene ID:27000
NCBI Accession:Q99543.4
UniProt Related Accession:Q99543
Molecular Weight:
NCBI Full Name:DnaJ homolog subfamily C member 2
NCBI Synonym Full Names:DnaJ heat shock protein family (Hsp40) member C2
NCBI Official Symbol:DNAJC2  
NCBI Official Synonym Symbols:ZRF1; ZUO1; MPP11; MPHOSPH11  
NCBI Protein Information:dnaJ homolog subfamily C member 2
UniProt Protein Name:DnaJ homolog subfamily C member 2
UniProt Synonym Protein Names:M-phase phosphoprotein 11; Zuotin-related factor 1DnaJ homolog subfamily C member 2, N-terminally processed
UniProt Gene Name:DNAJC2  
UniProt Entry Name:DNJC2_HUMAN
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