Anti-COL4A1 Antibody (CAB10710)
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주문- SKU:
- CAB10710
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
Antibody Name: | Anti-COL4A1 Antibody |
Antibody SKU: | CAB10710 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1445-1669 of human COL4A1 (NP_001836.2). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: | U-87 MG |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1445-1669 of human COL4A1 (NP_001836.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | GFLV TRHS QTID DPQC PSGT KILY HGYS LLYV QGNE RAHG QDLG TAGS CLRK FSTM PFLF CNIN NVCN FASR NDYS YWLS TPEP MPMS MAPI TGEN IRPF ISRC AVCE APAM VMAV HSQT IQIP PCPS GWSS LWIG YSFV MHTS AGAE GSGQ ALAS PGSC LEEF RSAP FIEC HGRG TCNY YANA YSFW LATI ERSE MFKK PTPS TLKA GELR THVS RCQV CMRR T |
Gene ID: | 1282 |
Uniprot: | P02462 |
Cellular Location: | Secreted, basement membrane, extracellular matrix, extracellular space |
Calculated MW: | 127kDa/160kDa |
Observed MW: | 160kDa |
Synonyms: | COL4A1, BSVD, RATOR |
Background: | This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a °Chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. |
NCBI Summary: | This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
UniProt Code: | P02462 |
NCBI GenInfo Identifier: | 125987809 |
NCBI Gene ID: | 1282 |
NCBI Accession: | P02462.3 |
UniProt Secondary Accession: | P02462,Q1P9S9, Q5VWF6, Q86X41, Q8NF88, Q9NYC5, A7E2W4 B1AM70, |
UniProt Related Accession: | P02462 |
Molecular Weight: | 127,981 Da |
NCBI Full Name: | Collagen alpha-1(IV) chain |
NCBI Synonym Full Names: | collagen type IV alpha 1 chain |
NCBI Official Symbol: | COL4A1 |
NCBI Official Synonym Symbols: | BSVD; RATOR |
NCBI Protein Information: | collagen alpha-1(IV) chain |
UniProt Protein Name: | Collagen alpha-1(IV) chain |
Protein Family: | Collagen |
UniProt Gene Name: | COL4A1 |
UniProt Entry Name: | CO4A1_HUMAN |
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