Anti-CBX4 Antibody (CAB5109)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- CAB5109
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Antibody Name: | Anti-CBX4 Antibody |
Antibody SKU: | CAB5109 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthesized peptide derived from human CBX4 |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | MCF7, 22Rv1, K-562, Mouse brain, Rat brain |
Immunogen: | A synthesized peptide derived from human CBX4 |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 8535 |
Uniprot: | O00257 |
Cellular Location: | |
Calculated MW: | 50kDa |
Observed MW: | 60KDa |
Synonyms: | NBP16, PC2 |
Background: |
UniProt Protein Function: | CBX4: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 6.3.2.-; SUMO ligase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: nucleoplasm; nucleus; PcG protein complex Molecular Function:enzyme binding; protein binding; SUMO binding; SUMO ligase activity; transcription corepressor activity Biological Process: negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein sumoylation |
UniProt Code: | O00257 |
NCBI GenInfo Identifier: | 254763424 |
NCBI Gene ID: | 8535 |
NCBI Accession: | O00257.3 |
UniProt Secondary Accession: | O00257,Q6TPI8, Q96C04, B1PJR7, |
UniProt Related Accession: | O00257 |
Molecular Weight: | 31,987 Da |
NCBI Full Name: | E3 SUMO-protein ligase CBX4 |
NCBI Synonym Full Names: | chromobox 4 |
NCBI Official Symbol: | CBX4 |
NCBI Official Synonym Symbols: | PC2; NBP16 |
NCBI Protein Information: | E3 SUMO-protein ligase CBX4 |
UniProt Protein Name: | E3 SUMO-protein ligase CBX4 |
UniProt Synonym Protein Names: | Chromobox protein homolog 4; Polycomb 2 homolog; Pc2; hPc2 |
Protein Family: | E3 SUMO-protein ligase |
UniProt Gene Name: | CBX4 |
UniProt Entry Name: | CBX4_HUMAN |
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