Anti-AXIN2 Antibody (RACO0134)
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주문- SKU:
- RACO0134
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Conjugation:
- Unconjugated
Description
Product Name: | AXIN2 Antibody |
Product SKU: | RACO0134 |
Size: | 50ul |
Host Species: | Human |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Human |
Immunogen: | A synthesized peptide derived from human AXIN2 |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity). |
Synonyms: | Axin-2, Axin-like protein, Axil, Axis inhibition protein 2, Conductin, AXIN2 |
UniProt Protein Function: | axin 2: is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Is downregulated during progression of esophageal squamous cell carcinoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 17q24.1 Cellular Component: nucleoplasm; microtubule cytoskeleton; Golgi apparatus; centrosome; cytoplasmic microtubule; cytoplasm; cytoplasmic membrane-bound vesicle; postsynaptic density; plasma membrane; cell cortex; cytosol; nucleus; beta-catenin destruction complex Molecular Function:protein binding; enzyme binding; ubiquitin protein ligase binding; beta-catenin binding; protein kinase binding; GTPase activator activity Biological Process: odontogenesis; negative regulation of cell proliferation; cell proliferation; intramembranous ossification; regulation of mismatch repair; mRNA stabilization; dorsal/ventral axis specification; negative regulation of osteoblast differentiation; positive regulation of protein amino acid phosphorylation; maintenance of DNA repeat elements; bone mineralization; positive regulation of GTPase activity Disease: Oligodontia-colorectal Cancer Syndrome |
NCBI Summary: | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y2T1 |
NCBI GenInfo Identifier: | 12643949 |
NCBI Gene ID: | 8313 |
NCBI Accession: | Q9Y2T1.1 |
UniProt Secondary Accession: | Q9Y2T1,Q3MJ88, Q9H3M6, Q9UH84, |
UniProt Related Accession: | Q9Y2T1 |
Molecular Weight: | 843 |
NCBI Full Name: | Axin-2 |
NCBI Synonym Full Names: | axin 2 |
NCBI Official Symbol: | AXIN2Â Â |
NCBI Official Synonym Symbols: | AXIL; ODCRCSÂ Â |
NCBI Protein Information: | axin-2; conductin; axin-like protein; axis inhibition protein 2 |
UniProt Protein Name: | Axin-2 |
UniProt Synonym Protein Names: | Axin-like protein; Axil; Axis inhibition protein 2; Conductin |
Protein Family: | Axin |
UniProt Gene Name: | AXIN2Â Â |
UniProt Entry Name: | AXIN2_HUMAN |