Anti-ASH2L Antibody (CAB4892)
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주문- SKU:
- CAB4892
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ASH2
- Synonyms:
- ASH2L1
- Synonyms:
- ASH2L2
- Synonyms:
- Bre2
Frequently bought together:
Description
| Product Name: | ASH2L Rabbit mAb |
| Product Code: | CAB4892 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ASH2, ASH2L1, ASH2L2, Bre2 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ASH2L |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | PC-3, Mouse lung, Mouse testis |
| Immunogen: | A synthesized peptide derived from human ASH2L |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9070 |
| Uniprot: | Q9UBL3 |
| Calculated MW: | 69kDa |
| Observed MW: | 65KDa/80KDa |
| UniProt Protein Function: | ASH2L: Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis. Interacts with HCFC1. Core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 and MLL3/MLL4. Each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 and MLL4), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with DPY30 and RBBP5; the interaction is direct. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with SETD1A and SETD1B. Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription regulation; Methyltransferase Chromosomal Location of Human Ortholog: 8p11.2 Cellular Component: histone methyltransferase complex; nucleoplasm; nucleus Molecular Function:beta-catenin binding; DNA binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding Biological Process: histone H3-K4 methylation; positive regulation of cell proliferation; response to DNA damage stimulus; response to estrogen stimulus; transcription from RNA polymerase II promoter |
| UniProt Code: | Q9UBL3 |
| NCBI GenInfo Identifier: | 32141382 |
| NCBI Gene ID: | 9070 |
| NCBI Accession: | Q9UBL3.1 |
| UniProt Secondary Accession: | Q9UBL3,O60659, O60660, Q96B62, A8K7C3, D3DSW9, |
| UniProt Related Accession: | Q9UBL3 |
| Molecular Weight: | 60,208 Da |
| NCBI Full Name: | Set1/Ash2 histone methyltransferase complex subunit ASH2 |
| NCBI Synonym Full Names: | ASH2 like histone lysine methyltransferase complex subunit |
| NCBI Official Symbol: | ASH2L |
| NCBI Official Synonym Symbols: | ASH2; Bre2; ASH2L1; ASH2L2 |
| NCBI Protein Information: | set1/Ash2 histone methyltransferase complex subunit ASH2 |
| UniProt Protein Name: | Set1/Ash2 histone methyltransferase complex subunit ASH2 |
| UniProt Synonym Protein Names: | ASH2-like protein |
| UniProt Gene Name: | ASH2L |
| UniProt Entry Name: | ASH2L_HUMAN |
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