ANLN Antibody (PACO15440)
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주문- SKU:
- PACO15440
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ANLN Antibody (PACO15440) |
Antibody SKU: | PACO15440 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human ANLN |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15440(ANLN Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Anillin, also known as scraps homolog, is an evolutionarily conserved Actin- binding protein required for cytokinesis that was first identified in Drosophila melanogaster. Anillin is a ubiquitously expressed protein with highest expression levels in the central nervous system. It is predominantly found in the nucleus and it localizes to the cleavage furrow during cytokinesis, forming a ring with the help of Rac GTPase. During cytokinesis, Anillin interacts with CD2AP and functions to concentrate Rho A and maintain the localization of active Myosin. In Anillin knockout cells the cleavage furrow fails to complete ingression. Anillin expression levels fluctuate with the cell cycle, peaking in mitosis. |
Synonyms: | anillin, actin binding protein |
UniProt Protein Function: | anillin: an actin binding protein that interacts with cleavage furrow proteins such as septins and may play a role in cytokinesis. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 7p15-p14 Cellular Component: nucleoplasm; intracellular membrane-bound organelle; contractile ring; actin cytoskeleton Molecular Function:actin binding Biological Process: mitosis; cytokinesis after mitosis; septin ring assembly; regulation of exit from mitosis; hemopoietic progenitor cell differentiation Disease: Focal Segmental Glomerulosclerosis 8 |
NCBI Summary: | This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] |
UniProt Code: | Q9NQW6 |
NCBI GenInfo Identifier: | 90111962 |
NCBI Gene ID: | 54443 |
NCBI Accession: | Q9NQW6.2 |
UniProt Secondary Accession: | Q9NQW6,Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0, |
UniProt Related Accession: | Q9NQW6 |
Molecular Weight: | 1124 |
NCBI Full Name: | Actin-binding protein anillin |
NCBI Synonym Full Names: | anillin, actin binding protein |
NCBI Official Symbol: | ANLN |
NCBI Official Synonym Symbols: | scra; FSGS8; Scraps |
NCBI Protein Information: | actin-binding protein anillin |
UniProt Protein Name: | Actin-binding protein anillin |
Protein Family: | Anillin |
UniProt Gene Name: | ANLN |
UniProt Entry Name: | ANLN_HUMAN |
Antibodies | ELISA Kits |
Anti-ANLN Antibody (CAB6524) | Human ANLN (Actin-binding protein anillin) ELISA Kit (HUFI05452) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |