ANAPC1 Antibody (PACO05055)
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주문- SKU:
- PACO05055
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ANAPC1 Antibody (PACO05055) |
Antibody SKU: | PACO05055 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:40000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from human APC1 around the non-phosphorylation site of S355. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ANAPC1; TSG24; Anaphase-promoting complex subunit 1; APC1; Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 protein |
UniProt Protein Function: | APC1: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC1 family. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 2q12.1 Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle |
NCBI Summary: | This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q9H1A4 |
NCBI GenInfo Identifier: | 37537845 |
NCBI Gene ID: | 64682 |
NCBI Accession: | Q9H1A4.1 |
UniProt Secondary Accession: | Q9H1A4,Q2M3H8, Q9BSE6, Q9H8D0, |
UniProt Related Accession: | Q9H1A4 |
Molecular Weight: | 1944 |
NCBI Full Name: | Anaphase-promoting complex subunit 1 |
NCBI Synonym Full Names: | anaphase promoting complex subunit 1 |
NCBI Official Symbol: | ANAPC1 |
NCBI Official Synonym Symbols: | APC1; MCPR; TSG24 |
NCBI Protein Information: | anaphase-promoting complex subunit 1; cyclosome subunit 1; mitotic checkpoint regulator; testis-specific gene 24 protein; anaphase-promoting complex 1 (meiotic checkpoint regulator) |
UniProt Protein Name: | Anaphase-promoting complex subunit 1 |
UniProt Synonym Protein Names: | Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 protein |
UniProt Gene Name: | ANAPC1 |
UniProt Entry Name: | APC1_HUMAN |