AMBRA1 Antibody (PACO15417)
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주문- SKU:
- PACO15417
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | AMBRA1 Antibody (PACO15417) |
Antibody SKU: | PACO15417 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human AMBRA1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lymphoma tissue using PACO15417(AMBRA1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Human AMBRA1, which encodes a deduced 1,269-amino acid, protein. Ambra1 was expressed throughout development in mice, with strong staining in the neuroepithelium. Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3. |
Synonyms: | autophagy/beclin-1 regulator 1 |
UniProt Protein Function: | AMBRA1: a WD40 protein that regulates autophagy and development of the nervous system. A highly conserved vertebrate protein whose expression is mostly confined to the neuroepithelium during early neurogenesis. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. Interacts with ATG6. Forms a complex with ATG6 and PIK3C3. Its functional inactivation in mouse is lethal in utero (starting from embryonic day 14.5), leading to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, and excessive apoptosis. Hyperproliferation followed by a wave of caspase-dependent cell death was the earliest detectable abnormality in the developing neuroepithelium. Five isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Autophagy; Vesicle Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: mitochondrial outer membrane; intracellular membrane-bound organelle; mitochondrion; cytoplasm; autophagic vacuole; phagocytic vesicle; axoneme; cytosol Molecular Function:protein binding; ubiquitin protein ligase binding Biological Process: neural tube development; negative regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase activity; autophagy; negative regulation of neuron apoptosis; cell differentiation |
UniProt Code: | Q9C0C7 |
NCBI GenInfo Identifier: | 166215833 |
NCBI Gene ID: | 55626 |
NCBI Accession: | Q9C0C7.2 |
UniProt Secondary Accession: | Q9C0C7,A2AH22, |
UniProt Related Accession: | Q9C0C7 |
Molecular Weight: | |
NCBI Full Name: | Activating molecule in BECN1-regulated autophagy protein 1 |
NCBI Synonym Full Names: | autophagy and beclin 1 regulator 1 |
NCBI Official Symbol: | AMBRA1 |
NCBI Official Synonym Symbols: | DCAF3; WDR94 |
NCBI Protein Information: | activating molecule in BECN1-regulated autophagy protein 1 |
UniProt Protein Name: | Activating molecule in BECN1-regulated autophagy protein 1 |
Protein Family: | Activating molecule in BECN1-regulated autophagy protein |
UniProt Gene Name: | AMBRA1 |
UniProt Entry Name: | AMRA1_HUMAN |