ALAS1 Antibody (PACO52994)
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주문- SKU:
- PACO52994
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ALAS1 Antibody (PACO52994) |
Antibody SKU: | PACO52994 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human 5-aminolevulinate synthase, nonspecific, mitochondrial protein (57-285AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human lung cancer using PACO52994 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO52994 at dilution of 1:100. |
Background: | cytoplasm, mitochondrial matrix, mitochondrion, nucleoplasm, 5-aminolevulinate synthase activity, identical protein binding, heme biosynthetic process, mitochondrion organization |
Synonyms: | 5-aminolevulinate synthase, nonspecific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid, synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1), ALAS1, ALAS3 ALASH |
UniProt Protein Function: | ALAS1: the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] |
UniProt Protein Details: | Protein type:EC 2.3.1.37; Amino Acid Metabolism - glycine, serine and threonine; Mitochondrial; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Transferase Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; cytoplasm Molecular Function:5-aminolevulinate synthase activity; pyridoxal phosphate binding Biological Process: mitochondrion organization and biogenesis; organelle organization and biogenesis; porphyrin metabolic process; cellular lipid metabolic process; protoporphyrinogen IX biosynthetic process; heme biosynthetic process |
NCBI Summary: | This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] |
UniProt Code: | P13196 |
NCBI GenInfo Identifier: | 122824 |
NCBI Gene ID: | 211 |
NCBI Accession: | P13196.2 |
UniProt Related Accession: | P13196 |
Molecular Weight: | 640 |
NCBI Full Name: | 5-aminolevulinate synthase, nonspecific, mitochondrial |
NCBI Synonym Full Names: | 5'-aminolevulinate synthase 1 |
NCBI Official Symbol: | ALAS1 |
NCBI Official Synonym Symbols: | ALAS; MIG4; ALAS3; ALASH |
NCBI Protein Information: | 5-aminolevulinate synthase, nonspecific, mitochondrial; ALAS-H; delta-ALA synthase 1; migration-inducing protein 4; 5-aminolevulinic acid synthase 1; delta-aminolevulinate synthase 1; aminolevulinate, delta-, synthase 1 |
UniProt Protein Name: | 5-aminolevulinate synthase, nonspecific, mitochondrial |
UniProt Synonym Protein Names: | 5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1 |
Protein Family: | Alanine--tRNA ligase |
UniProt Gene Name: | ALAS1 |
UniProt Entry Name: | HEM1_HUMAN |