UniProt Protein Function: | AKR7A2: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. |
UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.1.1.n11 Chromosomal Location of Human Ortholog: 1p36.13 Cellular Component: Golgi apparatus; mitochondrion; cytosol Molecular Function:electron carrier activity; aldehyde reductase activity; phenanthrene-9,10-epoxide hydrolase activity Biological Process: xenobiotic metabolic process; carbohydrate metabolic process; aldehyde metabolic process |
NCBI Summary: | The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. [provided by RefSeq, Oct 2011] |
UniProt Code: | O43488 |
NCBI GenInfo Identifier: | 38372871 |
NCBI Gene ID: | 8574 |
NCBI Accession: | O43488.3 |
UniProt Secondary Accession: | O43488,O75749, Q5TG63, |
UniProt Related Accession: | O43488 |
Molecular Weight: | 359 |
NCBI Full Name: | Aflatoxin B1 aldehyde reductase member 2 |
NCBI Synonym Full Names: | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) |
NCBI Official Symbol: | AKR7A2 |
NCBI Official Synonym Symbols: | AFAR; AKR7; AFAR1; AFB1-AR1 |
NCBI Protein Information: | aflatoxin B1 aldehyde reductase member 2; AFB1-AR 1; HEL-S-166mP; SSA reductase; aldoketoreductase 7; AFB1 aldehyde reductase 1; succinic semialdehyde reductase; aflatoxin beta1 aldehyde reductase; epididymis secretory sperm binding protein Li 166mP |
UniProt Protein Name: | Aflatoxin B1 aldehyde reductase member 2 |
UniProt Synonym Protein Names: | AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase; SSA reductase |
Protein Family: | Aflatoxin B1 aldehyde reductase |
UniProt Gene Name: | AKR7A2 |
UniProt Entry Name: | ARK72_HUMAN |