AKAP12 Antibody (PACO18925)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO18925
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | AKAP12 Antibody (PACO18925) |
Antibody SKU: | PACO18925 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human AKAP12 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18925(AKAP12 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HT29 cells, Primary antibody: PACO18925(AKAP12 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18925(AKAP12 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |
Synonyms: | A kinase (PRKA) anchor protein 12 |
UniProt Protein Function: | SSTR1: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. Belongs to the G-protein coupled receptor 1 family. Interacts with SKB1. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; Cell cycle regulation; GPCR, family 1 Chromosomal Location of Human Ortholog: 14q13 Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane Molecular Function:neuropeptide binding; somatostatin receptor activity Biological Process: glutamate signaling pathway; response to starvation; negative regulation of cell proliferation; G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; cell surface receptor linked signal transduction; cell-cell signaling; neuropeptide signaling pathway; forebrain development; digestion; cerebellum development; spermatogenesis; response to nutrient |
UniProt Code: | Q02952 |
NCBI GenInfo Identifier: | 21493022 |
NCBI Gene ID: | 9590 |
NCBI Accession: | NP_005091 |
UniProt Related Accession: | Q02952 |
Molecular Weight: | 35,345 Da |
NCBI Full Name: | A-kinase anchor protein 12 isoform 1 |
NCBI Synonym Full Names: | A kinase (PRKA) anchor protein 12 |
NCBI Official Symbol: | AKAP12 |
NCBI Official Synonym Symbols: | SSeCKS; AKAP250 |
NCBI Protein Information: | A-kinase anchor protein 12; A-kinase anchor protein, 250kDa; AKAP 250; Src-Suppressed C Kinase Substrate; kinase scaffold protein gravin; myasthenia gravis autoantigen gravin |
UniProt Protein Name: | Somatostatin receptor type 1 |
UniProt Synonym Protein Names: | SRIF-2 |
Protein Family: | Somatostatin receptor |
UniProt Gene Name: | SSTR1 |
UniProt Entry Name: | SSR1_HUMAN |