AKAP10 Antibody (PACO43805)
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주문- SKU:
- PACO43805
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | AKAP10 Antibody (PACO43805) |
Antibody SKU: | PACO43805 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human A-kinase anchor protein 10, mitochondrial protein (413-662AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: AKAP10 antibody at 7µg/ml Lane 1: 293T whole cell lysate Lane 2: Hela whole cell lysate Lane 3: HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 74 kDa Observed band size: 74 kDa | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43805 at dilution of 1:100 | |
Immunohistochemistry of paraffin-embedded human cervical cancer using PACO43805 at dilution of 1:100 |
Background: | Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-α proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). |
Synonyms: | A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10), AKAP10 |
UniProt Protein Function: | AKAP10: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase. Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD). Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 17p11.1 Cellular Component: mitochondrion; cytoplasm; plasma membrane; cytosol Biological Process: protein localization; signal transduction; blood coagulation Disease: Cardiac Conduction Defect |
NCBI Summary: | This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012] |
UniProt Code: | O43572 |
NCBI GenInfo Identifier: | 21493033 |
NCBI Gene ID: | 11216 |
NCBI Accession: | NP_009133.2 |
UniProt Secondary Accession: | O43572,Q96AJ7, B2R650, |
UniProt Related Accession: | O43572 |
Molecular Weight: | 73,818 Da |
NCBI Full Name: | A-kinase anchor protein 10, mitochondrial |
NCBI Synonym Full Names: | A kinase (PRKA) anchor protein 10 |
NCBI Official Symbol: | AKAP10 |
NCBI Official Synonym Symbols: | PRKA10; AKAP-10; D-AKAP2; D-AKAP-2 |
NCBI Protein Information: | A-kinase anchor protein 10, mitochondrial; protein kinase A anchoring protein 10; dual specificity A kinase-anchoring protein 2; mitochondrial A kinase PPKA anchor protein 10 |
UniProt Protein Name: | A-kinase anchor protein 10, mitochondrial |
UniProt Synonym Protein Names: | Dual specificity A kinase-anchoring protein 2; D-AKAP-2; Protein kinase A-anchoring protein 10; PRKA10 |
Protein Family: | A-kinase anchor protein |
UniProt Gene Name: | AKAP10 |
UniProt Entry Name: | AKA10_HUMAN |